Top-down mass spectrometry reveals multiple interactions of an acetylsalicylic acid bearing Zeise’s salt derivative with peptides
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biological Inorganic Chemistry"
DOI: 10.1007/s00775-020-01760-9
Abstract: Synergistic effects and promising anticancer activities encourage the combination of non-steroidal anti-inflammatory drugs with metallodrugs. Here, we discuss the interactions of an organometallic complex consisting of an acetylsalicylic acid (ASA) moiety attached to a Pt… read more here.
Keywords: top mass; zeise salt; acetylsalicylic acid; mass spectrometry ... See more keywords
Top-Down Mass Spectrometry for Trace Level Quantification of Staphylococcal Enterotoxin A Variants.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.1c00886
Abstract: We addressed here the need for improved sensitivity of top-down mass spectrometry for identification, differentiation, and absolute quantification of sequence variants of SEA, a bacterial toxin produced by Staphylococcus aureus and regularly involved in food… read more here.
Keywords: mass spectrometry; quantification; mass; enterotoxin ... See more keywords
Quantitative Top-Down Mass Spectrometry Identifies Proteoforms Differentially Released during Mechanical Stimulation of Mouse Skin.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.8b00109
Abstract: Mechanotransduction refers to the processes whereby mechanical stimuli are converted into electrochemical signals that allow for the sensation of our surrounding environment through touch. Despite its fundamental role in our daily lives, the molecular and… read more here.
Keywords: top mass; mass spectrometry; stimulation; stimulation mouse ... See more keywords
Evaluation of bottom-up and top-down mass spectrum identifications with different customized protein sequences databases
Sign Up to like & getrecommendations! Published in 2020 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btz733
Abstract: MOTIVATION Generally, bottom-up and top-down are two complementary approaches for proteoforms identification. The inference of proteoforms relies on searching mass spectra against an accurate proteoform sequence database. A customized protein sequence database derived by RNA-Seq… read more here.
Keywords: top mass; bottom top; mass; customized protein ... See more keywords