The Top1 paradox: Friend and foe of the eukaryotic genome.
Sign Up to like & getrecommendations! Published in 2017 at "DNA repair"
DOI: 10.1016/j.dnarep.2017.06.005
Abstract: Topoisomerases manage the torsional stress associated with the separation of DNA strands during transcription and DNA replication. Eukaryotic Topoisomerase I (Top1) is a Type IB enzyme that nicks and rejoins only one strand of duplex… read more here.
Keywords: eukaryotic genome; top1 paradox; paradox friend; dna ... See more keywords
Topoisomerase 1 activity during mitotic transcription favors the transition from mitosis to G1.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.10.015
Abstract: As cells enter mitosis, chromatin compacts to facilitate chromosome segregation yet remains transcribed. Transcription supercoils DNA to levels that can impede further progression of RNA polymerase II (RNAPII) unless it is removed by DNA topoisomerase… read more here.
Keywords: transcription; mitosis; top1; mitotic transcription ... See more keywords
Synthesis of Methoxy-, Methylenedioxy-, Hydroxy-, and Halo-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors and Their Biological Activity for Drug-Resistant Cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00318
Abstract: As a recently discovered DNA repair enzyme, tyrosyl-DNA phosphodiesterase 1 (TDP1) removes topoisomerase IB (TOP1)-mediated DNA protein cross-links. Inhibiting TDP1 can potentiate the cytotoxicity of TOP1 inhibitors and overcome cancer cell resistance to TOP1 inhibitors.… read more here.
Keywords: dna; top1; tdp1; cancer ... See more keywords
Strictosidine Synthase Triggered Enantioselective Synthesis of N-Substituted (S)-3,14,18,19-Tetrahydroangustines as Novel Topoisomerase I Inhibitors.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.7b00740
Abstract: Monoterpenoid indole alkaloids (MIAs) comprise an important class of molecules for drug discovery, and they have variant carbon skeletons with prominent bioactivities. For instance, in spite of limitations to their use, camptothecins are the only… read more here.
Keywords: synthase triggered; top1; triggered enantioselective; strictosidine synthase ... See more keywords
Deletions associated with stabilization of the Top1 cleavage complex in yeast are products of the nonhomologous end-joining pathway
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1914081116
Abstract: Significance The separation of DNA strands during replication and transcription creates torsional stress (supercoiling) that requires resolution by topoisomerases. Topoisomerase 1 (Top1) removes supercoils by transiently nicking one DNA strand, which allows its rotation around… read more here.
Keywords: end joining; stabilization; dna; cleavage ... See more keywords
NEDDylated Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abq0648
Abstract: DNA topoisomerase 1 (TOP11) inhibitors are mainstays of anticancer therapy. These drugs trap TOP1 on DNA, stabilizing the TOP1-cleavage complex (TOP1-cc). The accumulation of TOP1-ccs perturbs DNA replication fork progression, leading to DNA breaks and… read more here.
Keywords: dna; adaptive response; topoisomerase; top1 ... See more keywords
Abstract 4930: Foldamers mimicking the B-DNA surface as a new class of DNA topoisomerase I inhibitors
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4930
Abstract: DNA mimicry has been the subject of intensive research and resulted in the development of DNA analogues such as PNAs and LNAs. There are also examples of proteins with structural and/or charge distribution analogies with… read more here.
Keywords: inhibition; dna; dna mimics; new class ... See more keywords
Evodiamine and Rutaecarpine as Potential Anticancer Compounds: A Combined Computational Study
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911513
Abstract: Evodiamine (EVO) and rutaecarpine (RUT) are the main active compounds of the traditional Chinese medicinal herb Evodia rutaecarpa. Here, we fully optimized the molecular geometries of EVO and RUT at the B3LYP/6-311++G (d, p) level… read more here.
Keywords: rutaecarpine potential; evodiamine rutaecarpine; top1; anticancer ... See more keywords
TOP1 inhibition induces bifurcated JNK/MYC signaling that dictates cancer cell sensitivity
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.70583
Abstract: Rationale: Triple-negative breast cancer (TNBC) does not respond to anti-estrogen and anti-HER2 therapies and is commonly treated by chemotherapy. TNBC has a high recurrence rate, particularly within the first 3 years. Thus, there is an… read more here.
Keywords: inhibition; top1; tnbc; cancer cell ... See more keywords