Abstract 2794: Indotecan (LMP400), imidotecan (LMP776) and LMP744: A new class of non-camptothecin Top1 inhibitors selective for homologous recombination deficient (HRD) cells
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DOI: 10.1158/1538-7445.am2017-2794
Abstract: To relax DNA supercoiling during transcription and replication, topoisomerase I (Top1) induces transient DNA cleavage complexes, which are trapped by anticancer drugs, leading to DNA double-strand breaks (DSB) that need to be repaired by homologous… read more here.
Keywords: top1 inhibitors; deficient; homologous recombination; lmp776 lmp744 ... See more keywords