The Top1 paradox: Friend and foe of the eukaryotic genome.
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DOI: 10.1016/j.dnarep.2017.06.005
Abstract: Topoisomerases manage the torsional stress associated with the separation of DNA strands during transcription and DNA replication. Eukaryotic Topoisomerase I (Top1) is a Type IB enzyme that nicks and rejoins only one strand of duplex… read more here.
Keywords: eukaryotic genome; top1 paradox; paradox friend; dna ... See more keywords