SUMO-Targeted DNA Translocase Rrp2 Protects the Genome from Top2-Induced DNA Damage.
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DOI: 10.1016/j.molcel.2017.04.017
Abstract: The action of DNA topoisomerase II (Top2) creates transient DNA breaks that are normally concealed inside Top2-DNA covalent complexes. Top2 poisons, including ubiquitously present natural compounds and clinically used anti-cancer drugs, trap Top2-DNA complexes. Here,… read more here.
Keywords: dna; top2 dna; rrp2; dna translocase ... See more keywords