Targeting DNA topoisomerase IIα (TOP2A) in the hypoxic tumour microenvironment using unidirectional hypoxia‐activated prodrugs (uHAPs)
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DOI: 10.1002/iub.2619
Abstract: The hypoxic tumour microenvironment (hTME), arising from inadequate and chaotic vascularity, can present a major obstacle for the treatment of solid tumours. Hypoxic tumour cells compromise responses to treatment since they can generate resistance to… read more here.
Keywords: tumour microenvironment; unidirectional hypoxia; top2a; activated prodrugs ... See more keywords
Upregulation of endothelial cell-derived exosomal microRNA-125b-5p protects from sepsis-induced acute lung injury by inhibiting topoisomerase II alpha
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DOI: 10.1007/s00011-020-01415-0
Abstract: Objective Emerging evidence has revealed that exosomal microRNAs (miRNAs) are implicated in human diseases. However, role of exosomal miR-125b-5p in sepsis-induced acute lung injury (ALI) remains further explored. We focused on the effect of exosomal… read more here.
Keywords: mir 125b; lung; top2a; cell ... See more keywords
DNA topoisomerase II alpha promotes the metastatic characteristics of glioma cells by transcriptionally activating β-catenin
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DOI: 10.1080/21655979.2021.2023985
Abstract: ABSTRACT DNA topoisomerase II alpha (TOP2A) reportedly plays a crucial role in several cancers, however, the precise regulatory role of TOP2A in metastatic characteristics of glioma is still poorly understood. Herein, we sought to elucidate… read more here.
Keywords: topoisomerase alpha; top2a; characteristics glioma; dna topoisomerase ... See more keywords
Topoisomerase II alpha promotes gallbladder cancer proliferation and metastasis through activating phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway
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DOI: 10.1097/cm9.0000000000001075
Abstract: Abstract Background : Topoisomerase II alpha (TOP2A) has been reported to play a crucial role in the tumorigenesis of various cancer types. However, the biological role of TOP2A in gallbladder cancer (GBC) remains unknown. The… read more here.
Keywords: kinase; cancer; top2a; gbc ... See more keywords
The prognostic significance of topoisomerase II alpha protein in early stage luminal breast cancer
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DOI: 10.1186/s12885-018-4170-7
Abstract: BackgroundTopoisomerase II alpha (TOP2A) protein has been shown to be a proliferation marker associated with tumor grade and Ki67 index. The prognostic effect of TOP2A seems different among different subtypes of breast cancer. The current… read more here.
Keywords: luminal breast; breast cancer; top2a; cancer ... See more keywords
High expression of TOP2A gene predicted poor prognosis of hepatocellular carcinoma after radical hepatectomy
Sign Up to like & getrecommendations! Published in 2020 at "Translational cancer research"
DOI: 10.21037/tcr.2019.12.46
Abstract: Background: Topoisomerase (DNA) II alpha (TOP2A) is the up-regulated gene of the chromosome aggregation pathway. This gene encodes DNA topoisomerase, which can control and change the topological state of DNA during transcription and replication, participate… read more here.
Keywords: expression top2a; top2a expression; top2a; expression ... See more keywords
Prognostic Value and Significant Pathway Exploration Associated with TOP2A Involved in Papillary Thyroid Cancer
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DOI: 10.2147/ijgm.s316145
Abstract: Background Topoisomerase 2-alpha (TOP2A) has been identified as a hub gene that played an important role in the initiation and progression of thyroid carcinoma (THCA). However, the exact function of TOP2A in papillary thyroid cancer… read more here.
Keywords: expression; ptc; top2a; stage ... See more keywords
TOP2A correlates with poor prognosis and affects radioresistance of medulloblastoma
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DOI: 10.3389/fonc.2022.918959
Abstract: Radiotherapy remains the standard treatment for medulloblastoma (MB), and the radioresistance contributes to tumor recurrence and poor clinical outcomes. Nuclear DNA topoisomerase II-alpha (TOP2A) is a key catalytic enzyme that initiates DNA replication, and studies… read more here.
Keywords: top2a; high expression; medulloblastoma; poor prognosis ... See more keywords
A TOP2A-derived cancer panel drives cancer progression in papillary renal cell carcinoma.
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DOI: 10.3892/ol.2018.9179
Abstract: The aim of the present study was to investigate the function of the DNA topoisomerase IIα (TOP2A) gene and its associated genes in the progression of papillary renal cell carcinoma (PRCC). Online cancer databases, including… read more here.
Keywords: cancer; top2a; renal cell; cancer panel ... See more keywords
nm23, TOP2A and VEGF expression: Potential prognostic biologic factors in peripheral T-cell lymphoma, not otherwise specified.
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DOI: 10.3892/ol.2019.10703
Abstract: Peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) is an aggressive lymphoma associated with a poor outcome. To date, the factor consistently associated with prognosis is the International Prognostic Index (IPI) score; however, it is considered… read more here.
Keywords: expression; top2a; nm23 top2a; ptcl nos ... See more keywords