PTEN loss drives resistance to the neddylation inhibitor MLN4924 in glioblastoma and can be overcome with TOP2A inhibitors.
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DOI: 10.1093/neuonc/noac067
Abstract: BACKGROUND Neddylation inhibition, affecting posttranslational protein function and turnover, is a promising therapeutic approach to cancer. We report vulnerability to MLN4924 or pevonedistat (a neddylation inhibitor) in a subset of glioblastoma (GBM) preclinical models and… read more here.
Keywords: neddylation inhibitor; neddylation; top2a inhibitors; mln4924 ... See more keywords