Cytosolic TOP3α facilitates mitochondrial DNA sensing by cGAS
Sign Up to like & getrecommendations! Published in 2025 at "EMBO Reports"
DOI: 10.1038/s44319-025-00614-2
Abstract: Mitochondrial DNA (mtDNA) serves as a potent activator for cellular innate immune responses. Topoisomerase 3α (TOP3α), a type IA topoisomerase, is canonically localized to mitochondria and nuclei, but its enigmatic cytosolic fraction—observed over two decades… read more here.
Keywords: mtdna; cgas; cytosolic top3; top3 facilitates ... See more keywords
DNA topoisomerase Top3β is impacted by early life stress in the developing female and male rat brain
Sign Up to like & getrecommendations! Published in 2023 at "Brain Research"
DOI: 10.2139/ssrn.4237251
Abstract: DNA topoisomerases are essential for preserving genomic integrity. DNA topoisomerases induce breakage of DNA to facilitate replication and transcription by relaxing DNA and relieving supercoiling. Aberrant expression and deletions of topoisomerases are associated with psychiatric… read more here.
Keywords: dna; early life; brain; top3 ... See more keywords
Topoisomerase IIIβ Deficiency Induces Neuro-Behavioral Changes and Brain Connectivity Alterations in Mice
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms222312806
Abstract: Topoisomerase IIIβ (Top3β), the only dual-activity topoisomerase in mammals that can change topology of both DNA and RNA, is known to be associated with neurodevelopment and mental dysfunction in humans. However, there is no report… read more here.
Keywords: connectivity alterations; connectivity; top3; topoisomerase iii ... See more keywords