Molecular Evolution of DNA Topoisomerase III Beta (TOP3B) in Metazoa.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular evolution"
DOI: 10.1007/s00239-021-10011-7
Abstract: DNA topoisomerase III beta (TOP3B) is unique by operating on both DNA and RNA substrates to regulate gene expression and genomic stability. Mutations in human TOP3B are linked to neurodevelopmental and cognitive disorders, highlighting its… read more here.
Keywords: iii beta; evolution; topoisomerase iii; dna ... See more keywords
A dual-activity topoisomerase complex regulates mRNA translation and turnover.
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic acids research"
DOI: 10.1093/nar/gkac538
Abstract: Topoisomerase 3β (TOP3B) and TDRD3 form a dual-activity topoisomerase complex that interacts with FMRP and can change the topology of both DNA and RNA. Here, we investigated the post-transcriptional influence of TOP3B and associated proteins… read more here.
Keywords: top3b; topology; turnover; topoisomerase ... See more keywords
A dual-activity topoisomerase complex promotes both transcriptional activation and repression in response to starvation.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad086
Abstract: Topoisomerases are required to release topological stress generated by RNA polymerase II (RNAPII) during transcription. Here, we show that in response to starvation, the complex of topoisomerase 3b (TOP3B) and TDRD3 can enhance not only… read more here.
Keywords: top3b; transcriptional activation; topoisomerase; top3b tdrd3 ... See more keywords