USP13 regulates the replication stress response by deubiquitinating TopBP1.
Sign Up to like & getrecommendations! Published in 2021 at "DNA repair"
DOI: 10.1016/j.dnarep.2021.103063
Abstract: The DNA replication stress-induced checkpoint activated through the TopBP1-ATR axis is important for maintaining genomic stability. However, the regulation of TopBP1 in DNA-damage responses remains unclear. In this study, we identify the deubiquitinating enzyme (DUB)… read more here.
Keywords: topbp1; stress response; replication stress;
TopBP1 utilises a bipartite GINS binding mode to support genome replication
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-45946-0
Abstract: Activation of the replicative Mcm2-7 helicase by loading GINS and Cdc45 is crucial for replication origin firing, and as such for faithful genetic inheritance. Our biochemical and structural studies demonstrate that the helicase activator GINS… read more here.
Keywords: replication; origin firing; topbp1 utilises; topbp1 gins ... See more keywords
Interaction with TopBP1 Is Required for Human Papillomavirus 16 E2 Plasmid Segregation/Retention Function during Mitosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00830-22
Abstract: HPV16 causes 3% to 4% of all human cancers. It is proposed that during the viral life cycle, the viral genome is actively segregated into daughter nuclei, ensuring viral replication in the subsequent S phase.… read more here.
Keywords: interaction; function; interaction topbp1; topbp1 ... See more keywords