TopBP1 utilises a bipartite GINS binding mode to support genome replication
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-45946-0
Abstract: Activation of the replicative Mcm2-7 helicase by loading GINS and Cdc45 is crucial for replication origin firing, and as such for faithful genetic inheritance. Our biochemical and structural studies demonstrate that the helicase activator GINS… read more here.
Keywords: replication; origin firing; topbp1 utilises; topbp1 gins ... See more keywords