Efficacy and Safety of Topical Rapamycin in Patients With Facial Angiofibromas Secondary to Tuberous Sclerosis Complex: The TREATMENT Randomized Clinical Trial
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Dermatology"
DOI: 10.1001/jamadermatol.2018.0464
Abstract: Importance Facial angiofibromas occur in approximately 75% of individuals with tuberous sclerosis complex (TSC), causing substantial morbidity and disfigurement. Current therapies are partially effective, uncomfortable, produce scarring, and need repeating to treat recurrence. Objective To… read more here.
Keywords: topical rapamycin; trial; vehicle; group ... See more keywords
The efficacy and safety of topical rapamycin–calcitriol for facial angiofibromas in patients with tuberous sclerosis complex: a prospective, double‐blind, randomized clinical trial
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Dermatology"
DOI: 10.1111/bjd.18949
Abstract: The efficacy of topical rapamycin is well documented for tuberous sclerosis complex (TSC)‐related facial angiofibromas (FAs). Calcitriol has been shown to lessen skin fibrosis and may be therapeutically beneficial to FAs. read more here.
Keywords: topical rapamycin; tuberous sclerosis; sclerosis complex; efficacy ... See more keywords
Analysis of current data on the use of topical mTOR inhibitors in the treatment of facial angiofibromas in tuberous sclerosis complex—An update
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DOI: 10.1111/jdv.18693
Abstract: Tuberous sclerosis complex (TSC) is an autosomal dominant neurocutaneous syndrome causing hamartomatous growths in multiple organs. Facial angiofibromas occur in up to 80% of patients and can be highly disfiguring. Treatment for these lesions is… read more here.
Keywords: topical rapamycin; facial angiofibromas; use topical; treatment ... See more keywords
Topical rapamycin (sirolimus) for the treatment of uncomplicated tufted angiomas in two children and review of the literature
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DOI: 10.1111/pde.13596
Abstract: The mTOR inhibitor rapamycin is used systemically for the treatment of vascular lesions. We report the first use of topical rapamycin for the successful treatment of two cases of tufted angioma. The evidence for the… read more here.
Keywords: topical rapamycin; treatment uncomplicated; rapamycin sirolimus; sirolimus treatment ... See more keywords