Pathogenesis-based therapy: Cutaneous abnormalities of CHILD syndrome successfully treated with topical simvastatin monotherapy
Sign Up to like & getrecommendations! Published in 2018 at "JAAD Case Reports"
DOI: 10.1016/j.jdcr.2017.11.019
Abstract: The first description of this condition in 1948 was followed by 17 case reports before Happle delineated the key features and proposed the acronym CHILD syndrome in 1980, which stands for congenital hemidysplasia, ichthyosiform nevus,… read more here.
Keywords: child syndrome; topical simvastatin; cholesterol; pathogenesis ... See more keywords
Topical simvastatin–cholesterol for disseminated superficial actinic porokeratosis: An open‐label, split‐body clinical trial
Sign Up to like & getrecommendations! Published in 2021 at "Australasian Journal of Dermatology"
DOI: 10.1111/ajd.13601
Abstract: Disseminated superficial actinic porokeratosis (DSAP) is a porokeratosis variant that is cosmetically disfiguring and may be associated with squamous cell carcinoma. It is an autosomal dominant condition caused by germline mutations in mevalonate pathway genes… read more here.
Keywords: disseminated superficial; topical simvastatin; superficial actinic; cholesterol ... See more keywords
Topical Simvastatin Improves Lesions of Diffuse Normolipemic Plane Xanthoma by Inhibiting Foam Cell Pyroptosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.865704
Abstract: Xanthoma pathogenesis is speculated to be associated with oxidized low-density lipoprotein (ox-LDL) deposition, although this remains unclear. Most patients with diffuse plane xanthomas present elevated blood lipid levels, and they benefit from treatment with oral… read more here.
Keywords: foam cell; plane; topical simvastatin; simvastatin ... See more keywords