Efficacy and Safety of Topical Sirolimus Therapy for Facial Angiofibromas in the Tuberous Sclerosis Complex: A Randomized Clinical Trial
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Dermatology"
DOI: 10.1001/jamadermatol.2016.3545
Abstract: Importance Inhibitors of mammalian target of rapamycin complex 1, such as sirolimus, effectively target skin lesions in tuberous sclerosis complex (TSC). However, systemic treatment causes adverse effects, and topical sirolimus has shown promise in the… read more here.
Keywords: tuberous sclerosis; topical sirolimus; trial; treatment ... See more keywords
Treatment of Trichilemmomas With Topical Sirolimus.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2022.5701
Abstract: This case report describes a woman in her 60s flesh-colored papules that were localized to the central face and a lobular downgrowth of cells with clear, expanded, faintly glassy cytoplasm. read more here.
Keywords: dermatology; topical sirolimus; treatment trichilemmomas; trichilemmomas topical ... See more keywords
Long‐term treatment of cutaneous manifestations of tuberous sclerosis complex with topical 1% sirolimus cream: A prospective study of 25 patients
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Academy of Dermatology"
DOI: 10.1016/j.jaad.2017.04.005
Abstract: Background: Data on long‐term topical sirolimus treatment of the cutaneous manifestations of tuberous sclerosis complex are rare. Objective: To evaluate the long‐term benefit and tolerance of topical 1% sirolimus in tuberous sclerosis complex. Methods: In… read more here.
Keywords: tuberous sclerosis; topical sirolimus; long term; sclerosis complex ... See more keywords
Topical sirolimus for treatment of a solitary angiokeratoma
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DOI: 10.1111/dth.13907
Abstract: Angiokeratomas are benign vascular neoplasms that arise as solitary or multiple lesions, most commonly treated with excision, electrodessication, cryotherapy, or laser therapies. This case presents a young female whose solitary angiokeratoma was treated with topical… read more here.
Keywords: topical sirolimus; treatment solitary; sirolimus; sirolimus treatment ... See more keywords
Tuberous Sclerosis Complex in 29 Children: Clinical and Genetic Analysis and Facial Angiofibroma Responses to Topical Sirolimus
Sign Up to like & getrecommendations! Published in 2017 at "Pediatric Dermatology"
DOI: 10.1111/pde.13204
Abstract: Tuberous sclerosis complex (TSC) is a genetic disorder and facial angiofibromas are disfiguring facial lesions. The aim of this study was to analyze the clinical and genetic features of TSC and to assess the treatment… read more here.
Keywords: tuberous sclerosis; topical sirolimus; sclerosis complex; clinical genetic ... See more keywords
Topical sirolimus: Difference between compounded preparations and commercial oral solution
Sign Up to like & getrecommendations! Published in 2021 at "Pediatric Dermatology"
DOI: 10.1111/pde.14637
Abstract: Topical sirolimus has become a crucial treatment option for many dermatologic disorders. Because an FDA‐approved topical formulation is not commercially available, sirolimus creams, ointments, and gels are professionally prepared by compounding pharmacies. Also, the topical… read more here.
Keywords: topical sirolimus; oral solution; compounded preparations; sirolimus ... See more keywords
Efficacy and Safety of Topical Mechanistic Target of Rapamycin Inhibitors for Facial Angiofibromas in Patients with Tuberous Sclerosis Complex: A Systematic Review and Network Meta-Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10040826
Abstract: Previous studies have suggested that the topical mechanistic target of rapamycin (mTOR) inhibitors may be effective in treating facial angiofibromas in patients with tuberous sclerosis complex (TSC). Various concentrations of topical sirolimus for TSC have… read more here.
Keywords: topical sirolimus; facial angiofibromas; angiofibromas; analysis ... See more keywords