Monitoring Wound Healing with Topically Applied Optical NanoFlare mRNA Nanosensors
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202104835
Abstract: An effective wound management strategy needs accurate assessment of wound status throughout the whole healing process. This can be achieved by examining molecular biomarkers including proteins, DNAs, and RNAs. However, existing methods for quantifying these… read more here.
Keywords: applied optical; wound healing; mrna nanosensors; topically applied ... See more keywords
Microscopic investigation of" topically applied nanoparticles for molecular imaging of fresh tissue surfaces.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of biophotonics"
DOI: 10.1002/jbio.201700246
Abstract: Previous studies have shown that functionalized nanoparticles (NPs) topically applied on fresh tissues are able to rapidly target cell-surface protein biomarkers of cancer. Furthermore, studies have shown that a paired-agent approach, in which an untargeted… read more here.
Keywords: tissue surfaces; topically applied; molecular imaging; fresh tissues ... See more keywords
Quantitative determination of concentration profiles of skin components and topically applied oils by tailored multivariate curve resolution‐alternating least squares using in vivo confocal Raman micro‐spectroscopy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biophotonics"
DOI: 10.1002/jbio.202200219
Abstract: The main components of the stratum corneum (SC), water, lipids, and proteins, are non‐homogeneously distributed throughout the depth. The quantitative determination of their concentration profiles and penetration depth of topically applied substances are urgent topics… read more here.
Keywords: quantitative determination; spectroscopy; topically applied; raman ... See more keywords
Laser‐induced thermal coagulation enhances skin uptake of topically applied compounds
Sign Up to like & getrecommendations! Published in 2017 at "Lasers in Surgery and Medicine"
DOI: 10.1002/lsm.22642
Abstract: Ablative fractional laser (AFL) generates microchannels in skin surrounded by a zone of thermally altered tissue, termed the coagulation zone (CZ). The thickness of CZ varies according to applied wavelength and laser settings. It is… read more here.
Keywords: coagulation; uptake topically; topically applied; induced thermal ... See more keywords
Topically applied azaphenothiazines inhibit experimental psoriasis in mice
Sign Up to like & getrecommendations! Published in 2018 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2018.03.028
Abstract: ABSTRACT The therapeutic efficacy of topically applied azaphenothiazine derivatives: 9‐chloro‐6‐acetylaminobutylquinobenzo[3,2‐b][1,4]thiazine (compound 4) and 6‐chloroethylureidoethyldiquino[3,2‐b;2′;3′‐e][1,4]thiazine (compound 5) in the amelioration of inflammatory symptoms of imiquimod‐induced psoriasis in mice was investigated. Clobederm®, containing clobetasol propioniate, served as… read more here.
Keywords: topically applied; azaphenothiazines inhibit; compound; mice ... See more keywords
Topically applied linoleic/linolenic acid for chronic migraine
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2018.10.013
Abstract: The topical application of linoleic and linolenic acids is a potential prophylactic approach to migraine via an anti-inflammatory mechanism. We present a 45-year-old woman with chronic migraine without aura. Previous use of abortive or prophylactic… read more here.
Keywords: migraine; topically applied; linoleic linolenic; chronic migraine ... See more keywords
Topically applied adipose-derived mesenchymal stem cell treatment in experimental focal cerebral ischemia
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2019.08.051
Abstract: Abstract In this study, the neuro-modulation effect of topical mesenchymal stem cells (MSCs) was tested in a rodent middle carotid artery occlusion (MCAO) model. Twenty-four hours after MCAO, craniotomy was made and 0.8 × 106 GFP-MSCs were… read more here.
Keywords: derived mesenchymal; topically applied; applied adipose; adipose derived ... See more keywords
Topical application of mesenchymal stem cell exosomes alleviates the imiquimod induced psoriasis-like inflammation
Sign Up to like & getrecommendations! Published in 2021 at "Cytotherapy"
DOI: 10.1016/s1465324921004436
Abstract: Severe psoriasis, a chronic inflammatory skin disease is increasingly being effectively managed by targeted immunotherapy but long-term immunotherapy poses health risk and loss of response. Therefore, there is a need for alternative therapy strategies. Mesenchymal… read more here.
Keywords: stratum corneum; msc exosomes; topically applied; psoriasis ... See more keywords
Standardization of an in vitro Model for Evaluating the Bioavailability of Topically Applied Compounds on Damaged Skin: Application to Sunscreen Analysis
Sign Up to like & getrecommendations! Published in 2017 at "Skin Pharmacology and Physiology"
DOI: 10.1159/000455196
Abstract: Background: Information is lacking on the dermal penetration of topically applied formulations on in vitro skin models, under conditions where the stratum corneum (SC) is damaged. Therefore, we have developed a standardized in vitro barrier-disrupted… read more here.
Keywords: standardization vitro; topically applied; bioavailability; tape stripping ... See more keywords
Environmental Fate and Dissipation of Applied dsRNA in Soil, Aquatic Systems, and Plants
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2020.00021
Abstract: Two primary use patterns exist for dsRNA-based products for crop protection: in planta produced dsRNA such as in a genetically engineered (GE) crop; and topically applied dsRNA such as a spray application. To enable effective… read more here.
Keywords: environmental fate; degradation; environmental compartments; topically applied ... See more keywords
Parametric Drug Release Optimization of Anti-Inflammatory Drugs by Gold Nanoparticles for Topically Applied Ocular Therapy
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232416191
Abstract: Eye drops represent 90% of all currently used ophthalmic treatments. Only 0.02% of therapeutic molecules contained in eye drops reach the eye anterior chamber despite their high concentration. The tear film efficiently protects the cornea,… read more here.
Keywords: topically applied; drug; drug release; gold nanoparticles ... See more keywords