The effects of Topiramate on isolation-induced aggression: a behavioral and immunohistochemical study in mice
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05546-4
Abstract: Topiramate, an antiepileptic drug, has been found to be useful for the treatment of aggression in clinical populations. Most preclinical studies related to Topiramate have been focused exclusively on the quantitative aspects of the aggressive… read more here.
Keywords: induced aggression; mice; topiramate; behavior ... See more keywords
Use of Topiramate in the Spectrum of Addictive and Eating Disorders: A Systematic Review Comparing Treatment Schemes, Efficacy, and Safety Features
Sign Up to like & getrecommendations! Published in 2021 at "CNS Drugs"
DOI: 10.1007/s40263-020-00780-y
Abstract: Topiramate has been approved by the US Food and Drug Administration for the treatment of epilepsy since the 1990s, and it has also been used off-label in the treatment of many types of addictive disorders.… read more here.
Keywords: treatment; disorder; systematic review; topiramate ... See more keywords
Granuloma Annulare Possibly Secondary to Oral Treatment With Topiramate.
Sign Up to like & getrecommendations! Published in 2017 at "Actas dermo-sifiliograficas"
DOI: 10.1016/j.ad.2017.03.016
Abstract: Granuloma annulare (GA) is a benign and typically selflimiting granulomatous disease of unknown etiology; it tends to resolve spontaneously over a period of months or years. It usually presents with annular lesions on the hands,… read more here.
Keywords: treatment topiramate; topiramate; granuloma annulare;
Nephrolithiasis and Nephrocalcinosis From Topiramate Therapy in Children With Epilepsy
Sign Up to like & getrecommendations! Published in 2018 at "Kidney International Reports"
DOI: 10.1016/j.ekir.2018.02.005
Abstract: Introduction Adults treated with topiramate may develop nephrolithiasis, but its frequency in children on topiramate is unknown. Topiramate inhibits renal carbonic anhydrase, which can lead to renal tubular acidosis and hypercalciuria. We studied 40 consecutive… read more here.
Keywords: therapy; calcium creatinine; urinary calcium; calcium ... See more keywords
Experimental measurement, thermodynamic analysis and molecular simulation of topiramate solubility in fourteen mono-solvents at various temperatures
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2021.116992
Abstract: Abstract A novel antiepileptic drug of topiramate (TPM) has remarkably boosted the human health to against epilepsy. Herein, the solubility of TPM was measured in fourteen mono-solvents through a method of laser monitoring at temperatures… read more here.
Keywords: tpm; fourteen mono; solubility; mono solvents ... See more keywords
Efficacy and safety of topiramate in binge eating disorder: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2020 at "CNS Spectrums"
DOI: 10.1017/s1092852920001613
Abstract: Abstract Background To assess the efficacy and safety of topiramate in treating binge eating disorder (BED), using a systematic review and meta-analysis of the available randomized clinical trials (RCTs). Methods The RCTs assessing topiramate vs… read more here.
Keywords: efficacy safety; binge; systematic review; topiramate ... See more keywords
Prospective randomized pharmacogenetic study of topiramate for treating alcohol use disorder
Sign Up to like & getrecommendations! Published in 2021 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-020-00945-9
Abstract: In a prior study, topiramate reduced heavy drinking among individuals who sought to reduce their drinking, with the effect moderated by a single nucleotide polymorphism (SNP; rs2832407) in GRIK1, which encodes the kainate GluK1 receptor… read more here.
Keywords: study topiramate; study; topiramate; alcohol use ... See more keywords
Topiramate affords neuroprotection in diabetic neuropathy model via downregulating spinal GFAP/inflammatory burden and improving neurofilament production.
Sign Up to like & getrecommendations! Published in 2023 at "Toxicology mechanisms and methods"
DOI: 10.1080/15376516.2023.2196687
Abstract: The current study aimed to test the neuroprotective action of topiramate in mouse peripheral diabetic neuropathy (DN) and explored some mechanisms underlying this action. Mice were assigned as vehicle group, DN group, DN + topiramate 10-mg/kg and… read more here.
Keywords: topiramate affords; diabetic neuropathy; topiramate; affords neuroprotection ... See more keywords
A Double-Blind Placebo-Controlled Pilot Study of Topiramate in Manic Adolescents Treated with Olanzapine.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of child and adolescent psychopharmacology"
DOI: 10.1089/cap.2022.0098
Abstract: Objective: To conduct a pilot study to examine topiramate for the treatment of weight gain associated with olanzapine in manic adolescents with bipolar disorder. Methods: We conducted a 12-week double-blind randomized placebo-controlled pilot study of… read more here.
Keywords: manic adolescents; placebo; topiramate; pilot study ... See more keywords
Preclinical pharmacokinetics and tolerability of a novel meglumine‐based parenteral solution of topiramate and topiramate combinations for treatment of status epilepticus
Sign Up to like & getrecommendations! Published in 2023 at "Epilepsia"
DOI: 10.1111/epi.17520
Abstract: For an antiseizure medication (ASM) to be effective in status epilepticus (SE), the drug should be administered intravenously (i.v.) to provide quick access to the brain. However, poor aqueous solubility is a major problem in… read more here.
Keywords: status epilepticus; meglumine; topiramate; solution ... See more keywords
Short-term adjunct of topiramate to antipsychotics in schizophrenia improves the psychopathology and has weight maintenance
Sign Up to like & getrecommendations! Published in 2017 at "Evidence-Based Mental Health"
DOI: 10.1136/eb-2017-102624
Abstract: ABSTRACT FROM: Zheng W, Xiang YT, Xiang YQ, et al. Efficacy and safety of adjunctive topiramate for schizophrenia: a meta-analysis of randomized controlled trials. Acta Psychiatr Scand 2016;134:385–98. Although a previous meta-analysis showed that topiramate-antipsychotic… read more here.
Keywords: short term; topiramate; controlled trials; psychopathology ... See more keywords