The design of TOPK inhibitors using structure-based pharmacophore modeling and molecular docking based on an MD-refined homology model.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular diversity"
DOI: 10.1007/s11030-021-10361-w
Abstract: The TOPK enzyme (also known as PBK) is a serine-threonine protein kinase that is rarely detected in normal tissues yet is found to be overexpressed and activated in a variety of cancers such as lung,… read more here.
Keywords: using structure; topk; structure; structure based ... See more keywords
Novel selective TOPK inhibitor SKLB-C05 inhibits colorectal carcinoma growth and metastasis.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.12.016
Abstract: The mitogen-activated protein kinase (MAPK) signaling pathway member T-LAK cell-originated protein kinase/PDZ-binding kinase (TOPK/PBK) is closely involved in tumorigenesis and progression. Its overexpression in colorectal carcinoma (CRC) exacerbates tumor malignancy, promotes metastasis and results in… read more here.
Keywords: topk; sklb c05; kinase; crc ... See more keywords
Suppression of the solar ultraviolet-induced skin carcinogenesis by TOPK inhibitor HI-TOPK-032
Sign Up to like & getrecommendations! Published in 2020 at "Oncogene"
DOI: 10.1038/s41388-020-1286-4
Abstract: Nonmelanoma skin cancer (NMSC) such as cutaneous squamous cell carcinoma (cSCC) is caused by solar ultraviolet (SUV) exposure and is the most common cancer in the United States. T-LAK cell-originated protein kinase (TOPK), a serine-threonine… read more here.
Keywords: solar ultraviolet; skin carcinogenesis; topk; induced skin ... See more keywords
Targeting TOPK sensitises tumour cells to radiation-induced damage by enhancing replication stress
Sign Up to like & getrecommendations! Published in 2020 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-020-00655-1
Abstract: T-LAK-originated protein kinase (TOPK) overexpression is a feature of multiple cancers, yet is absent from most phenotypically normal tissues. As such, TOPK expression profiling and the development of TOPK-targeting pharmaceutical agents have raised hopes for… read more here.
Keywords: replication stress; topk; damage; replication ... See more keywords
Novel biomarker, phosphorylated T‐LAK cell‐originated protein kinase (p‐TOPK) can predict outcome in primary central nervous system lymphoma
Sign Up to like & getrecommendations! Published in 2018 at "Neuropathology"
DOI: 10.1111/neup.12463
Abstract: This study aimed to assess whether T‐lymphokine‐activated killer cell‐originated protein kinase (TOPK) can be a potent novel biomarker to predict the outcome in patients with primary central nervous system lymphoma (PCNSL). This study enrolled 20… read more here.
Keywords: cell originated; outcome; topk; originated protein ... See more keywords
TOPK Affects Autophagy of Skin Squamous Cell Carcinoma by Regulating NF-KB Pathway through HDAC1
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/3771711
Abstract: Objective To explore the effect and potential mechanism of T-LAK cell-originated protein kinase (TOPK) on autophagy in cutaneous squamous cell carcinoma (cSCC). Methods Human cSCC cancer tissue and paracancerous tissue samples were collected clinically; immunohistochemistry… read more here.
Keywords: cell carcinoma; cscc; p65; squamous cell ... See more keywords
Abstract 4650: TOPK is a prognostic marker and therapeutic target in skin carcinogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2019-4650
Abstract: Solar ultraviolet (sUV) is linked to development of cutaneous squamous cell carcinoma (cSCC) as a non-melanoma skin cancer (NMSC). Actinic keratosis (AK), induced by sUV irradiation, acts as precursor to cutaneous squamous cell carcinoma (cSCC)… read more here.
Keywords: mice; skin; target; topk ... See more keywords
Abstract 6380: Suppression of the solar ultraviolet-induced skin carcinogenesis by TOPK inhibitor HI-TOPK-032
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-6380
Abstract: Non-melanoma skin cancer (NMSC) such as cutaneous squamous cell carcinoma (cSCC) is caused by solar ultraviolet (SUV) exposure and is the most common cancer in the United States. T-LAK cell-originated protein kinase (TOPK), a serine-threonine… read more here.
Keywords: solar ultraviolet; skin carcinogenesis; topk; cancer ... See more keywords
TOPK promotes metastasis of esophageal squamous cell carcinoma by activating the Src/GSK3β/STAT3 signaling pathway via γ-catenin
Sign Up to like & getrecommendations! Published in 2019 at "BMC Cancer"
DOI: 10.1186/s12885-019-6453-z
Abstract: Esophageal squamous cell carcinoma (ESCC) is a fatal disease with poor prognosis. The predominant reason for ESCC-related death is distal metastasis. A comprehensive understanding of the molecular mechanism underlying metastasis is needed for improving patient… read more here.
Keywords: metastasis; topk; src gsk3; escc ... See more keywords
Gossypetin Inhibits Solar-UV Induced Cutaneous Basal Cell Carcinoma Through Direct Inhibiting PBK/TOPK Protein Kinase.
Sign Up to like & getrecommendations! Published in 2019 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520619666190301123131
Abstract: Skin photoaging, skin inflammation and skin cancer are related with excessive exposure to solar ultraviolet light (solar-UV). PDZ-binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK), a member of the serine/threonine protein kinase, which regulates the signaling cascades… read more here.
Keywords: kinase; solar induced; topk; phosphor ... See more keywords