The design of TOPK inhibitors using structure-based pharmacophore modeling and molecular docking based on an MD-refined homology model.
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DOI: 10.1007/s11030-021-10361-w
Abstract: The TOPK enzyme (also known as PBK) is a serine-threonine protein kinase that is rarely detected in normal tissues yet is found to be overexpressed and activated in a variety of cancers such as lung,… read more here.
Keywords: using structure; topk; structure; structure based ... See more keywords