Nitric oxide inhibits ATPase activity and induces resistance to topoisomerase II-poisons in human MCF-7 breast tumor cells
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2017.04.011
Abstract: Background Topoisomerase poisons are important drugs for the management of human malignancies. Nitric oxide (•NO), a physiological signaling molecule, induces nitrosylation (or nitrosation) of many cellular proteins containing cysteine thiol groups, altering their cellular functions.… read more here.
Keywords: tumor cells; topoisomerase poisons; topo; nitric oxide ... See more keywords
Dihydroxylated 2,6-diphenyl-4-chlorophenylpyridines: Topoisomerase I and IIα dual inhibitors with DNA non-intercalative catalytic activity.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.03.048
Abstract: With the aim to develop novel antiproliferative agents, a new series of eighteen dihydroxylated 2,6-diphenyl-4-chlorophenylpyridines were systematically designed, prepared, and investigated for their topoisomerase (topo) I and IIα inhibitory properties and antiproliferative effect in three… read more here.
Keywords: diphenyl chlorophenylpyridines; topo topo; dihydroxylated diphenyl; topo ... See more keywords
Design, synthesis and biological evaluation of 4-amidobenzimidazole acridine derivatives as dual PARP and Topo inhibitors for cancer therapy.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.07.050
Abstract: PARP-1 could repair the DNA damages induced by Topo inhibitors, therefore inhibiting Topo and PARP-1 simultaneously might be able to overcome resistance and improve outcomes. In this study a series of 4-amidobenzimidazole acridines were designed… read more here.
Keywords: topo parp; parp; topo inhibitors; topo ... See more keywords
Extraction kinetics and mechanism of Zr and Hf by DIBK−TOPO system using Lewis Cell
Sign Up to like & getrecommendations! Published in 2018 at "Separation Science and Technology"
DOI: 10.1080/01496395.2018.1453841
Abstract: ABSTRACT Kinetics studies on the extraction of Zr and Hf using the mixture of diisobutyl ketone (DIBK) and trioctylphosphine oxide (TOPO) as extractant were performed in a Lewis Cell. The results showed that the extraction… read more here.
Keywords: extraction; reaction; rate; topo ... See more keywords
THU0327 ANTIBODIES AGAINST EXTRACTABLE NUCLEAR ANTIGENS (ENA) IN SCLERODERMA ARE NOT ONLY DIAGNOSTIC AND PROGNOSTIC TOOLS, BUT PATHOGENETIC REGULATORS INDUCING A PROFIBROTIC PHENOTYPE IN CULTURED SKIN FIBROBLASTS
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.3521
Abstract: Background The importance of systemic sclerosis (SSc) autoantibodies for diagnosis has become increasingly recognized, as evidence by incorporation into the 2013 ACR/EULAR clinical classification criteria (1). Clear prognostic and phenotypic associations with cutaneous subtype and… read more here.
Keywords: control; lcssc; cenp topo; topo ... See more keywords
POS0853 DECREASE IN ANTI-TOPOISOMERASE-1 ANTIBODY TITER IN PATIENTS WITH SYSTEMIC SCLEROSIS DURING LONG-TERM RITUXIMAB THERAPY
Sign Up to like & getrecommendations! Published in 2021 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2021-eular.2038
Abstract: Rituximab (RTX) is a new option in the treatment of systemic sclerosis (SSc) [1]. There is not enough data on changes in the level of autoantibodies and their clinical significance during RTM therapy. There are… read more here.
Keywords: therapy; rtx; systemic sclerosis; topo ... See more keywords
Functionally Active Antibodies to the Angiotensin II Type 1-Receptor Measured by a Luminometric Bioassay Do Not Correlate With Clinical Manifestations in Systemic Sclerosis: A Comparison With Antibodies to Vascular Receptors and Topoisomerase I Detected by ELISA
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.786039
Abstract: Objectives 1) To detect functionally active antibodies(abs) to the angiotensin II type-1-receptor (AT1R) by a novel luminometric assay. 2) To assess their prevalence in systemic sclerosis (SSc), other collagen disorders, as well as in further… read more here.
Keywords: anti at1r; topo; functionally active; at1r eta1 ... See more keywords
Single-nucleotide resolution detection of Topo IV cleavage activity in the Escherichia coli genome with Topo-Seq
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2023.1160736
Abstract: Topoisomerase IV (Topo IV) is the main decatenation enzyme in Escherichia coli; it removes catenation links that are formed during DNA replication. Topo IV binding and cleavage sites were previously identified in the E. coli… read more here.
Keywords: cleavage; topo cleavage; coli genome; escherichia coli ... See more keywords
Discovery of DNA Topoisomerase I Inhibitors with Low-Cytotoxicity Based on Virtual Screening from Natural Products
Sign Up to like & getrecommendations! Published in 2017 at "Marine Drugs"
DOI: 10.3390/md15070217
Abstract: Currently, DNA topoisomerase I (Topo I) inhibitors constitute a family of antitumor agents with demonstrated clinical effects on human malignancies. However, the clinical uses of these agents have been greatly limited due to their severe… read more here.
Keywords: virtual screening; natural products; cytotoxic; dna topoisomerase ... See more keywords
Discovery of Quinacrine as a Potent Topo II and Hsp90 Dual-Target Inhibitor, Repurposing for Cancer Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27175561
Abstract: Topo II and Hsp90 are promising targets. In this study, we first verified the structural similarities between Topo IIα ATPase and Hsp90α N−ATPase. Subsequently, 720 compounds from the Food and Drug Administration (FDA) drug library… read more here.
Keywords: hsp90; topo hsp90; target inhibitor; dual target ... See more keywords
Synergistic Extraction of Samarium(III) from Water via Emulsion Liquid Membrane Using a Low-Concentration D2EHPA–TOPO System: Operational Parameters and Salt Effects
Sign Up to like & getrecommendations! Published in 2025 at "Separations"
DOI: 10.3390/separations12090233
Abstract: The synergistic effect of using D2EHPA and TOPO together to enhance the extraction of samarium(III) from aqueous media via emulsion liquid membrane (ELM) technology was explored. D2EHPA in binary mixtures with TBP and in ternary… read more here.
Keywords: samarium iii; emulsion; extraction; topo ... See more keywords