Nitric oxide inhibits ATPase activity and induces resistance to topoisomerase II-poisons in human MCF-7 breast tumor cells
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2017.04.011
Abstract: Background Topoisomerase poisons are important drugs for the management of human malignancies. Nitric oxide (•NO), a physiological signaling molecule, induces nitrosylation (or nitrosation) of many cellular proteins containing cysteine thiol groups, altering their cellular functions.… read more here.
Keywords: tumor cells; topoisomerase poisons; topo; nitric oxide ... See more keywords
Dihydroxylated 2,6-diphenyl-4-chlorophenylpyridines: Topoisomerase I and IIα dual inhibitors with DNA non-intercalative catalytic activity.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.03.048
Abstract: With the aim to develop novel antiproliferative agents, a new series of eighteen dihydroxylated 2,6-diphenyl-4-chlorophenylpyridines were systematically designed, prepared, and investigated for their topoisomerase (topo) I and IIα inhibitory properties and antiproliferative effect in three… read more here.
Keywords: diphenyl chlorophenylpyridines; topo topo; dihydroxylated diphenyl; topo ... See more keywords
Design, synthesis and biological evaluation of 4-amidobenzimidazole acridine derivatives as dual PARP and Topo inhibitors for cancer therapy.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.07.050
Abstract: PARP-1 could repair the DNA damages induced by Topo inhibitors, therefore inhibiting Topo and PARP-1 simultaneously might be able to overcome resistance and improve outcomes. In this study a series of 4-amidobenzimidazole acridines were designed… read more here.
Keywords: topo parp; parp; topo inhibitors; topo ... See more keywords
Extraction kinetics and mechanism of Zr and Hf by DIBK−TOPO system using Lewis Cell
Sign Up to like & getrecommendations! Published in 2018 at "Separation Science and Technology"
DOI: 10.1080/01496395.2018.1453841
Abstract: ABSTRACT Kinetics studies on the extraction of Zr and Hf using the mixture of diisobutyl ketone (DIBK) and trioctylphosphine oxide (TOPO) as extractant were performed in a Lewis Cell. The results showed that the extraction… read more here.
Keywords: extraction; reaction; rate; topo ... See more keywords
THU0327 ANTIBODIES AGAINST EXTRACTABLE NUCLEAR ANTIGENS (ENA) IN SCLERODERMA ARE NOT ONLY DIAGNOSTIC AND PROGNOSTIC TOOLS, BUT PATHOGENETIC REGULATORS INDUCING A PROFIBROTIC PHENOTYPE IN CULTURED SKIN FIBROBLASTS
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.3521
Abstract: Background The importance of systemic sclerosis (SSc) autoantibodies for diagnosis has become increasingly recognized, as evidence by incorporation into the 2013 ACR/EULAR clinical classification criteria (1). Clear prognostic and phenotypic associations with cutaneous subtype and… read more here.
Keywords: control; lcssc; cenp topo; topo ... See more keywords
POS0853 DECREASE IN ANTI-TOPOISOMERASE-1 ANTIBODY TITER IN PATIENTS WITH SYSTEMIC SCLEROSIS DURING LONG-TERM RITUXIMAB THERAPY
Sign Up to like & getrecommendations! Published in 2021 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2021-eular.2038
Abstract: Rituximab (RTX) is a new option in the treatment of systemic sclerosis (SSc) [1]. There is not enough data on changes in the level of autoantibodies and their clinical significance during RTM therapy. There are… read more here.
Keywords: therapy; rtx; systemic sclerosis; topo ... See more keywords
Functionally Active Antibodies to the Angiotensin II Type 1-Receptor Measured by a Luminometric Bioassay Do Not Correlate With Clinical Manifestations in Systemic Sclerosis: A Comparison With Antibodies to Vascular Receptors and Topoisomerase I Detected by ELISA
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.786039
Abstract: Objectives 1) To detect functionally active antibodies(abs) to the angiotensin II type-1-receptor (AT1R) by a novel luminometric assay. 2) To assess their prevalence in systemic sclerosis (SSc), other collagen disorders, as well as in further… read more here.
Keywords: anti at1r; topo; functionally active; at1r eta1 ... See more keywords
Single-nucleotide resolution detection of Topo IV cleavage activity in the Escherichia coli genome with Topo-Seq
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2023.1160736
Abstract: Topoisomerase IV (Topo IV) is the main decatenation enzyme in Escherichia coli; it removes catenation links that are formed during DNA replication. Topo IV binding and cleavage sites were previously identified in the E. coli… read more here.
Keywords: cleavage; topo cleavage; coli genome; escherichia coli ... See more keywords
Discovery of DNA Topoisomerase I Inhibitors with Low-Cytotoxicity Based on Virtual Screening from Natural Products
Sign Up to like & getrecommendations! Published in 2017 at "Marine Drugs"
DOI: 10.3390/md15070217
Abstract: Currently, DNA topoisomerase I (Topo I) inhibitors constitute a family of antitumor agents with demonstrated clinical effects on human malignancies. However, the clinical uses of these agents have been greatly limited due to their severe… read more here.
Keywords: virtual screening; natural products; cytotoxic; dna topoisomerase ... See more keywords
Discovery of Quinacrine as a Potent Topo II and Hsp90 Dual-Target Inhibitor, Repurposing for Cancer Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27175561
Abstract: Topo II and Hsp90 are promising targets. In this study, we first verified the structural similarities between Topo IIα ATPase and Hsp90α N−ATPase. Subsequently, 720 compounds from the Food and Drug Administration (FDA) drug library… read more here.
Keywords: hsp90; topo hsp90; target inhibitor; dual target ... See more keywords
Markers of proliferation and invasiveness in somatotropinomas.
Sign Up to like & getrecommendations! Published in 2018 at "Endokrynologia Polska"
DOI: 10.5603/ep.a2018.0001
Abstract: Introduction In the search for markers of invasiveness of pituitary adenomas, we studied the expression of Ki-67 antigen, TOPO 2A (topoisomerase 2 alpha), AIP (Aryl Hydrocarbon Receptor-Interacting Protein) and VEGF (Vascular Endothelial Growth Factor) in… read more here.
Keywords: topo aip; aip vegf; expression; topo ... See more keywords