Discovery of Quinacrine as a Potent Topo II and Hsp90 Dual-Target Inhibitor, Repurposing for Cancer Therapy
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DOI: 10.3390/molecules27175561
Abstract: Topo II and Hsp90 are promising targets. In this study, we first verified the structural similarities between Topo IIα ATPase and Hsp90α N−ATPase. Subsequently, 720 compounds from the Food and Drug Administration (FDA) drug library… read more here.
Keywords: hsp90; topo hsp90; target inhibitor; dual target ... See more keywords