Design, synthesis and biological evaluation of 4-amidobenzimidazole acridine derivatives as dual PARP and Topo inhibitors for cancer therapy.
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DOI: 10.1016/j.ejmech.2017.07.050
Abstract: PARP-1 could repair the DNA damages induced by Topo inhibitors, therefore inhibiting Topo and PARP-1 simultaneously might be able to overcome resistance and improve outcomes. In this study a series of 4-amidobenzimidazole acridines were designed… read more here.
Keywords: topo parp; parp; topo inhibitors; topo ... See more keywords