Molecular Evolution of DNA Topoisomerase III Beta (TOP3B) in Metazoa.
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DOI: 10.1007/s00239-021-10011-7
Abstract: DNA topoisomerase III beta (TOP3B) is unique by operating on both DNA and RNA substrates to regulate gene expression and genomic stability. Mutations in human TOP3B are linked to neurodevelopmental and cognitive disorders, highlighting its… read more here.
Keywords: iii beta; evolution; topoisomerase iii; dna ... See more keywords
Topoisomerase IIIβ Deficiency Induces Neuro-Behavioral Changes and Brain Connectivity Alterations in Mice
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DOI: 10.3390/ijms222312806
Abstract: Topoisomerase IIIβ (Top3β), the only dual-activity topoisomerase in mammals that can change topology of both DNA and RNA, is known to be associated with neurodevelopment and mental dysfunction in humans. However, there is no report… read more here.
Keywords: connectivity alterations; connectivity; top3; topoisomerase iii ... See more keywords