Synthesis, human topoisomerase IIα inhibitory properties and molecular modeling studies of anti-proliferative curcumin mimics
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DOI: 10.1039/c9ra05661k
Abstract: Piperidinecarboxamides (curcumin mimics) show promising anti-proliferative properties against HCT116 (colon), MCF7 (breast) and A431 (squamous skin) carcinoma cell lines with potency higher than that of 5-fluorouracil. read more here.
Keywords: human topoisomerase; anti proliferative; synthesis human; topoisomerase inhibitory ... See more keywords
Precursor-Directed Generation of Indolocarbazoles with Topoisomerase IIα Inhibitory Activity
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DOI: 10.3390/md16050168
Abstract: One new indolocarbazole, 3-hydroxy-K252d (3), together with the recently reported 3-hydroxyholyrine A (1) and 3′-N-acetyl-3-hydroxyholyrine A (2), were obtained by feeding a culture of the marine-derived Streptomyces strain OUCMDZ-3118 with 5-hydroxy-l-tryptophan. Their structures were elucidated… read more here.
Keywords: precursor directed; directed generation; topoisomerase inhibitory; indolocarbazoles topoisomerase ... See more keywords