Nitric oxide inhibits ATPase activity and induces resistance to topoisomerase II-poisons in human MCF-7 breast tumor cells
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DOI: 10.1016/j.bbrep.2017.04.011
Abstract: Background Topoisomerase poisons are important drugs for the management of human malignancies. Nitric oxide (•NO), a physiological signaling molecule, induces nitrosylation (or nitrosation) of many cellular proteins containing cysteine thiol groups, altering their cellular functions.… read more here.
Keywords: tumor cells; topoisomerase poisons; topo; nitric oxide ... See more keywords