Discovery and Biological Evaluations of Halogenated 2,4-Diphenyl Indeno[1,2-b]pyridinol Derivatives as Potent Topoisomerase IIα-targeted Chemotherapeutic Agents for Breast Cancer.
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DOI: 10.1021/acs.jmedchem.9b00970
Abstract: With the aim of developing new effective topoisomerase IIα-targeted anticancer agents, we synthesized a series of hydroxy- and halogenated 2,4-diphenyl indeno[1,2-b]pyridinols using a microwave-assisted single step synthetic method, and investigated structure-activity relationships. The majority of… read more here.
Keywords: topoisomerase targeted; halogenated diphenyl; breast cancer; topoisomerase ... See more keywords
Mechanisms underlying synergy between DNA topoisomerase I-targeted drugs and mTOR kinase inhibitors in NF1-associated malignant peripheral nerve sheath tumors
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DOI: 10.1038/s41388-019-0965-5
Abstract: Malignant peripheral nerve sheath tumors (MPNSTs) are soft-tissue sarcomas that frequently arise in patients with neurofibromatosis type 1 (NF1). Most of these tumors are unresectable at diagnosis and minimally responsive to conventional treatment, lending urgency… read more here.
Keywords: drugs mtor; topoisomerase targeted; dna topoisomerase; nerve sheath ... See more keywords