Design, Synthesis, and Structure-Activity relationships of Evodiamine-Based topoisomerase (Top)/Histone deacetylase (HDAC) dual inhibitors.
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DOI: 10.1016/j.bioorg.2022.105702
Abstract: On the basis of synergistic effect between topoisomerase (Top) and histone deacetylase (HDAC) inhibitors, a series of novel evodiamine-based Top/HDAC dual inhibitors were designed and synthesized. Systematic structure-activity relationship (SAR) studies led to the discovery… read more here.
Keywords: topoisomerase top; evodiamine based; hdac dual; dual inhibitors ... See more keywords