Mutant-selective topologic conversion facilitates selective degradation of a pathogenic prion isoform
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DOI: 10.1038/s41418-019-0354-1
Abstract: Regulating protein import across the endoplasmic reticulum (ER) membrane occasionally results in the synthesis of topologically unnatural variants, and their accumulation often leads to proteotoxicity. However, since this is a regulated process, it is questionable… read more here.
Keywords: degradation; selective topologic; topologic conversion; prion ... See more keywords