Transcriptomic Analysis of CRISPR/Cas9-Mediated PARP1-Knockout Cells under the Influence of Topotecan and TDP1 Inhibitor
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DOI: 10.3390/ijms24065148
Abstract: Topoisomerase 1 (TOP1) is an enzyme that regulates DNA topology and is essential for replication, recombination, and other processes. The normal TOP1 catalytic cycle involves the formation of a short-lived covalent complex with the 3′… read more here.
Keywords: parp1 knockout; tdp1; parp1; topotecan tdp1 ... See more keywords