TOR signaling regulates liquid phase separation of the SMN complex governing snRNP biogenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109277
Abstract: The activity of the SMN complex in promoting the assembly of pre-mRNA processing UsnRNPs correlates with condensation of the complex in nuclear Cajal bodies. While mechanistic details of its activity have been elucidated, the molecular… read more here.
Keywords: phase separation; liquid phase; smn complex; smn ... See more keywords
Diverse nitrogen signals activate convergent ROP2-TOR signaling in Arabidopsis.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental cell"
DOI: 10.1016/j.devcel.2021.03.022
Abstract: The evolutionarily conserved target-of-rapamycin (TOR) kinase coordinates cellular and organismal growth in all eukaryotes. Amino acids (AAs) are key upstream signals for mammalian TOR activation, but how nitrogen-related nutrients regulate TOR signaling in plants is… read more here.
Keywords: nitrogen; signals activate; tor signaling; diverse nitrogen ... See more keywords
Diphthamide promotes TOR signaling by increasing the translation of proteins in the TORC1 pathway
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2104577118
Abstract: Significance Diphthamide is a posttranslational modification that has been known since the 1970s. It is conserved in all eukaryotic cells, and its biosynthesis requires at least seven proteins. However, its exact biological function has remained… read more here.
Keywords: torc1 pathway; tor signaling; translation; diphthamide promotes ... See more keywords
A Glucose-TOR Signaling Axis Integrates Environmental History of Heat Stress Through Maintenance of Transcription-Associated Epigenetic Memory in Arabidopsis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of experimental botany"
DOI: 10.1093/jxb/erac338
Abstract: In nature, plants cope with adversity and have established strategies that recall past episodes and enable them to better cope with stress recurrences by establishing a 'stress memory'. Emerging evidence suggests that Glucose (Glc) and… read more here.
Keywords: stress; heat stress; tor signaling; tor ... See more keywords
PRR5, 7 and 9 positively modulate TOR signaling-mediated root cell proliferation by repressing TANDEM ZINC FINGER 1 in Arabidopsis
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz191
Abstract: Abstract Circadian clock coordinates numerous plant growth and developmental processes including cell elongation in the hypocotyl, whether or not it modulates cell proliferation is largely unknown. Here we have found that Pseudo Response Regulators (PRRs),… read more here.
Keywords: cell proliferation; tor signaling; tandem zinc; tor ... See more keywords
Cross-Talk and Multiple Control of Target of Rapamycin (TOR) in Sclerotinia sclerotiorum
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00013-23
Abstract: TOR is a conserved protein kinase that regulates cell growth and metabolism in response to growth factors and nutrient abundance. Here, we used gene silencing to characterize SsTOR, which is a critical component of TOR… read more here.
Keywords: cell growth; tor signaling; tor; sclerotiorum ... See more keywords
Research progress on the relationship between the TOR signaling pathway regulator, epigenetics, and tumor development
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.1006936
Abstract: Almost all cellular activities depend on protein folding, signaling complex assembly/disassembly, and epigenetic regulation. One of the most important regulatory mechanisms responsible for controlling these cellular processes is dynamic protein phosphorylation/dephosphorylation. Alterations in phosphorylation networks… read more here.
Keywords: signaling pathway; tor signaling; tor; pp2a ... See more keywords
Dietary Aflatoxin B1 attenuates immune function of immune organs in grass carp (Ctenopharyngodon idella) by modulating NF-κB and the TOR signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1027064
Abstract: Aflatoxin B1 (AFB1) is kind of a common mycotoxin in food and feedstuff. Aquafeeds are susceptible to contamination of AFB1. In teleost fish, the spleen and head kidney are key immune organ. Moreover, the fish… read more here.
Keywords: dietary afb1; tor signaling; grass carp; immune organs ... See more keywords
Structural Insights into TOR Signaling
Sign Up to like & getrecommendations! Published in 2020 at "Genes"
DOI: 10.3390/genes11080885
Abstract: The Target of Rapamycin (TOR) is a highly conserved serine/threonine protein kinase that performs essential roles in the control of cellular growth and metabolism. TOR acts in two distinct multiprotein complexes, TORC1 and TORC2 (mTORC1… read more here.
Keywords: insights tor; structural insights; tor signaling; biology ... See more keywords