Blockade of M4 muscarinic receptors on striatal cholinergic interneurons normalizes striatal dopamine release in a mouse model of TOR1A dystonia
Sign Up to like & getrecommendations! Published in 2022 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2022.105699
Abstract: Trihexyphenidyl (THP), a non-selective muscarinic receptor (mAChR) antagonist, is commonly used for the treatment of dystonia associated with TOR1A, otherwise known as DYT1 dystonia. A better understanding of the mechanism of action of THP is… read more here.
Keywords: tor1a dystonia; release; striatal dopamine; dopamine release ... See more keywords