Indirect monitoring of TORC1 signalling pathway reveals molecular diversity among different yeast strains
Sign Up to like & getrecommendations! Published in 2019 at "Yeast"
DOI: 10.1002/yea.3351
Abstract: Saccharomyces cerevisiae is the main species responsible for the alcoholic fermentation in wine production. One of the main problems in this process is the deficiency of nitrogen sources in the grape must, which can lead… read more here.
Keywords: torc1; monitoring torc1; signalling pathway; pathway ... See more keywords
Yeast Ataxin-2 Forms an Intracellular Condensate Required for the Inhibition of TORC1 Signaling during Respiratory Growth
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2019.02.043
Abstract: Yeast ataxin-2, also known as Pbp1 (polyA binding protein-binding protein 1), is an intrinsically disordered protein implicated in stress granule formation, RNA biology, and neurodegenerative disease. To understand the endogenous function of this protein, we… read more here.
Keywords: torc1; torc1 signaling; respiratory growth; yeast ataxin ... See more keywords
The GATA Transcription Factor Gaf1 Represses tRNAs, Inhibits Growth, and Extends Chronological Lifespan Downstream of Fission Yeast TORC1
Sign Up to like & getrecommendations! Published in 2020 at "Cell Reports"
DOI: 10.1016/j.celrep.2020.02.058
Abstract: Summary Target of Rapamycin Complex 1 (TORC1) signaling promotes growth and aging. Inhibition of TORC1 leads to reduced protein translation, which promotes longevity. TORC1-dependent post-transcriptional regulation of protein translation has been well studied, while analogous… read more here.
Keywords: torc1; growth; fission yeast; factor gaf1 ... See more keywords
A spatially and functionally distinct pool of TORC1 defines signaling endosomes in yeast
Sign Up to like & getrecommendations! Published in 2019 at "Autophagy"
DOI: 10.1080/15548627.2019.1580107
Abstract: ABSTRACT The evolutionarily conserved target of rapamycin complex 1 (TORC1) regulates cell growth in a homeostatic manner by tuning anabolic and catabolic processes in response to nutritional and hormonal cues. Interestingly, rather than being localized… read more here.
Keywords: torc1; distinct pool; spatially functionally; functionally distinct ... See more keywords
Feedback regulation of TORC1 by its downstream effectors Npr1 and Par32
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e18-03-0158
Abstract: TORC1 (target of rapamycin complex) integrates complex nutrient signals to generate and fine-tune a growth and metabolic response. Npr1 (nitrogen permease reactivator) is a downstream effector kinase of TORC1 that regulates the stability, activity, and… read more here.
Keywords: torc1; feedback regulation; npr1 par32; downstream ... See more keywords
Multilayered regulation of TORC1-body formation in budding yeast
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e18-05-0297
Abstract: The target of rapamycin kinase complex 1 (TORC1) regulates cell growth and metabolism in eukaryotes. In Saccharomyces cerevisiae, TORC1 activity is known to be controlled by the conserved GTPases, Gtr1/2, and movement into and out… read more here.
Keywords: body formation; body; regulation; torc1 body ... See more keywords
The Social Network of TORC1 in plants.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of experimental botany"
DOI: 10.1093/jxb/erac278
Abstract: The Target Of Rapamycin Complex 1 (TORC1) is a highly conserved serine-threonine protein kinase crucial for coordinating growth according to nutrient availability in eukaryotes. TORC1 works as a central integrator of multiple nutrient inputs such… read more here.
Keywords: torc1; network; social network; torc1 signaling ... See more keywords
Human gasdermin D and MLKL disrupt mitochondria, endocytic traffic and TORC1 signalling in budding yeast
Sign Up to like & getrecommendations! Published in 2022 at "Open Biology"
DOI: 10.1098/rsob.220366
Abstract: Gasdermin D (GSDMD) and mixed lineage kinase domain-like protein (MLKL) are the pore-forming effectors of pyroptosis and necroptosis, respectively, with the capacity to disturb plasma membrane selective permeability and induce programmed cell death. The budding… read more here.
Keywords: gasdermin; gsdmd; torc1; mlkl ... See more keywords
Snf1/AMPK fine-tunes TORC1 signaling in response to glucose starvation
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.10.18.512649
Abstract: The AMP-activated protein kinase (AMPK) and the target of rapamycin complex 1 (TORC1) are central kinase modules of two opposing signaling pathways that control eukaryotic cell growth and metabolism in response to the availability of… read more here.
Keywords: glucose starvation; torc1; snf1; growth ... See more keywords
The TORC1 activates Rpd3L complex to deacetylate Ino80 and H2A.Z and repress autophagy
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.ade8312
Abstract: Autophagy is a critical process to maintain homeostasis, differentiation, and development. How autophagy is tightly regulated by nutritional changes is poorly understood. Here, we identify chromatin remodeling protein Ino80 and histone variant H2A.Z as the… read more here.
Keywords: ino80; torc1; repress; rpd3l complex ... See more keywords
TORC1 inhibition enhances immune function and reduces infections in the elderly
Sign Up to like & getrecommendations! Published in 2018 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aaq1564
Abstract: Treating elderly subjects with two low-dose mTOR inhibitors that selectively block TORC1 led to a decrease in infection rates. Dialing down TORC1 dials up immunity Aging may be regulated by a discrete set of intracellular… read more here.
Keywords: torc1; low dose; inhibition; mtor ... See more keywords