Splicing Factor 1 Modulates Dietary Restriction and TORC1 Pathway Longevity in C. elegans
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature20789
Abstract: Ageing is driven by a loss of transcriptional and protein homeostasis and is the key risk factor for multiple chronic diseases. Interventions that attenuate or reverse systemic dysfunction associated with age therefore have the potential… read more here.
Keywords: homeostasis; restriction; splicing factor; torc1 pathway ... See more keywords
Diphthamide promotes TOR signaling by increasing the translation of proteins in the TORC1 pathway
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2104577118
Abstract: Significance Diphthamide is a posttranslational modification that has been known since the 1970s. It is conserved in all eukaryotic cells, and its biosynthesis requires at least seven proteins. However, its exact biological function has remained… read more here.
Keywords: torc1 pathway; tor signaling; translation; diphthamide promotes ... See more keywords