Articles with "torc2" as a keyword



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Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2

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Published in 2017 at "Nature Communications"

DOI: 10.1038/s41467-017-01862-0

Abstract: The target of rapamycin (TOR) kinase assembles into two distinct multiprotein complexes, conserved across eukaryote evolution. In contrast to TOR complex 1 (TORC1), TORC2 kinase activity is not inhibited by the macrolide rapamycin. Here, we… read more here.

Keywords: torc2; target rapamycin; structure; tor ... See more keywords

Stress-response transcription factors Msn2 and Msn4 couple TORC2-Ypk1 signaling and mitochondrial respiration to ATG8 gene expression and autophagy

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Published in 2017 at "Autophagy"

DOI: 10.1080/15548627.2017.1356949

Abstract: ABSTRACT Macroautophagy/autophagy is a starvation and stress-induced catabolic process critical for cellular homeostasis and adaptation. Several Atg proteins are involved in the formation of the autophagosome and subsequent degradation of cytoplasmic components, a process termed… read more here.

Keywords: torc2; msn2 msn4; ypk1; expression ... See more keywords
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Roles of phosphatidylserine and phospholipase C in the activation of TOR complex 2 signaling in Saccharomyces cerevisiae.

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Published in 2022 at "Journal of cell science"

DOI: 10.1242/jcs.259988

Abstract: The target of rapamycin (TOR) forms two distinct complexes, TORC1 and TORC2, to exert its functions essential for cellular growth and homeostasis. TORC1 signaling is regulated in response to nutrients such as amino acids and… read more here.

Keywords: pkc1; tor; torc2; torc2 ypk1 ... See more keywords
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Environmental control of Pub1 (NEDD4 family E3 ligase) in Schizosaccharomyces pombe is regulated by TORC2 and Gsk3

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Published in 2022 at "Life Science Alliance"

DOI: 10.26508/lsa.202101082

Abstract: The NEDD4 family E3 ligase Pub1 is regulated by the nutrient environment, TORC2, and Gsk3 signalling pathway to control the level of amino acid transporters on the plasma membrane and thus nutrient uptake. Cells respond… read more here.

Keywords: nedd4 family; control; gsk3; pub1 ... See more keywords