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Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01862-0
Abstract: The target of rapamycin (TOR) kinase assembles into two distinct multiprotein complexes, conserved across eukaryote evolution. In contrast to TOR complex 1 (TORC1), TORC2 kinase activity is not inhibited by the macrolide rapamycin. Here, we…
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Keywords:
torc2;
target rapamycin;
structure;
tor ... See more keywords
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Published in 2017 at "Autophagy"
DOI: 10.1080/15548627.2017.1356949
Abstract: ABSTRACT Macroautophagy/autophagy is a starvation and stress-induced catabolic process critical for cellular homeostasis and adaptation. Several Atg proteins are involved in the formation of the autophagosome and subsequent degradation of cytoplasmic components, a process termed…
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Keywords:
torc2;
msn2 msn4;
ypk1;
expression ... See more keywords
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Published in 2022 at "Journal of cell science"
DOI: 10.1242/jcs.259988
Abstract: The target of rapamycin (TOR) forms two distinct complexes, TORC1 and TORC2, to exert its functions essential for cellular growth and homeostasis. TORC1 signaling is regulated in response to nutrients such as amino acids and…
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Keywords:
pkc1;
tor;
torc2;
torc2 ypk1 ... See more keywords
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2
Published in 2022 at "Life Science Alliance"
DOI: 10.26508/lsa.202101082
Abstract: The NEDD4 family E3 ligase Pub1 is regulated by the nutrient environment, TORC2, and Gsk3 signalling pathway to control the level of amino acid transporters on the plasma membrane and thus nutrient uptake. Cells respond…
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Keywords:
nedd4 family;
control;
gsk3;
pub1 ... See more keywords