Effect of mesoporous silica nanoparticles co-loading with 17-AAG and Torin2 on anaplastic thyroid carcinoma by targeting VEGFR2
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DOI: 10.3892/or.2020.7537
Abstract: Anaplastic thyroid carcinoma (ATC) is a highly aggressive tumor with a poor prognosis and a low median survival rate because of insufficient effective therapeutic modalities. Recently, mesoporous silica nanoparticles (MSNs) as a green non-toxic and… read more here.
Keywords: anaplastic thyroid; torin2 msns; aag torin2; thyroid carcinoma ... See more keywords
Torin2 inhibits the EGFR-TKI resistant Non-Small Lung Cancer cell proliferation through negative feedback regulation of Akt/mTOR signaling
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DOI: 10.7150/jca.37417
Abstract: It is known that mammalian target of rapamycin (mTOR) signaling plays an important role in NSCLC cells proliferation. Torin2 is a second-generation ATP-competitive inhibitor which is selective for mTOR activity. In this study, we investigated… read more here.
Keywords: tki resistant; mtor signaling; proliferation; torin2 ... See more keywords