Predicting critical drug concentrations and torsadogenic risk using a multiscale exposure-response simulator.
Sign Up to like & getrecommendations! Published in 2019 at "Progress in biophysics and molecular biology"
DOI: 10.1016/j.pbiomolbio.2018.10.003
Abstract: Torsades de pointes is a serious side effect of many drugs that can trigger sudden cardiac death, even in patients with structurally normal hearts. Torsadogenic risk has traditionally been correlated with the blockage of a… read more here.
Keywords: risk; exposure response; response simulator; torsadogenic risk ... See more keywords
Drug-induced QT prolongation: Concordance of preclinical anesthetized canine model in relation to published clinical observations for ten CiPA drugs.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmacological and toxicological methods"
DOI: 10.1016/j.vascn.2020.106871
Abstract: INTRODUCTION The Comprehensive In Vitro Proarrhythmia Assay (CiPA) initiative differentiates torsadogenic risk of 28 drugs affecting ventricular repolarization based on multiple in vitro human derived ionic currents. However, a standardized prospective assessment of the electrophysiologic… read more here.
Keywords: qtc prolongation; torsadogenic risk; model; ten cipa ... See more keywords