Development of a strategy for the total chemical synthesis of an allergenic protein: the peach LTP Pru p 3
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Peptide Science"
DOI: 10.1002/psc.2981
Abstract: The possibility to obtain allergenic proteins by means of total chemical synthesis would be a big step forward in the development of cures to food allergy and in the study of the mechanism of allergic… read more here.
Keywords: total chemical; allergenic protein; synthesis allergenic; chemical synthesis ... See more keywords
Total chemical and semisynthetic approaches for the preparation of ubiquitinated proteins and their applications
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DOI: 10.1007/s11426-017-9122-3
Abstract: Protein ubiquitination is an important post-translational modification (PTM) in eukaryotic organisms that regulates a variety of cellular processes, such as protein degradation, signal transduction, apoptosis, and DNA damage tolerance. To decipher mechanistically the diverse biological… read more here.
Keywords: semisynthetic approaches; total chemical; ubiquitinated proteins; chemical semisynthetic ... See more keywords
Total Chemical Synthesis of Palmitoyl-Conjugated Insulin
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DOI: 10.1021/acsomega.2c07918
Abstract: Commercially available insulins are manufactured by recombinant methods for the treatment of diabetes. Long-acting insulin drugs (e.g., detemir and degludec) are obtained by fatty acid conjugation at LysB29 ε-amine of insulin via acid–amide coupling. There… read more here.
Keywords: insulin; synthesis palmitoyl; palmitoyl; chemical synthesis ... See more keywords
Total Chemical Synthesis and Folding of All-l and All-d Variants of Oncogenic KRas(G12V).
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b02988
Abstract: The Ras proteins are essential GTPases involved in the regulation of cell proliferation and survival. Mutated oncogenic forms of Ras alter effector binding and innate GTPase activity, leading to deregulation of downstream signal transduction. Mutated… read more here.
Keywords: total chemical; variants oncogenic; oncogenic kras; chemical synthesis ... See more keywords
Total Chemical Synthesis of a Non-Fibrillating Human Glycoinsulin.
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DOI: 10.1021/jacs.9b11424
Abstract: Glycosylation is an accepted strategy to improve the therapeutic value of peptide and protein drugs. Insulin and its analogues are life-saving drugs for all type I and 30% of type II diabetic patients. However, they… read more here.
Keywords: insulin; synthesis non; total chemical; non fibrillating ... See more keywords