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ACROSIN deficiency causes total fertilization failure in humans by preventing the sperm from penetrating the zona pellucida.

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2 Published in 2023 at "Human reproduction"

DOI: 10.1093/humrep/dead059

Abstract: STUDY QUESTION Does a homozygous nonsense mutation in ACR lead to total fertilization failure (TFF) resulting in male infertility in humans? SUMMARY ANSWER A novel homozygous nonsense mutation of ACR (c.167G>A, p.Trp56X) was identified in… read more here.

Keywords: acrosin; fertilization; fertilization failure; acrosin deficiency ... See more keywords

Novel variants in ACTL7A and PLCZ1 are associated with male infertility and total fertilization failure

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3 Published in 2023 at "Clinical Genetics"

DOI: 10.1111/cge.14293

Abstract: Total fertilization failure (TFF), which refers to fertilization failure in all mature oocytes, accounting for 5%–10% of in vitro fertilization (IVF) cycles and 1%–3% of intracytoplasmic sperm injection (ICSI) cycles in human. In this study,… read more here.

Keywords: fertilization failure; plcz1 associated; actl7a plcz1; total fertilization ... See more keywords

Relationship between sperm quality and total fertilization failure in intracytoplasmic sperm injection and in vitro fertilization cycles: A cross-sectional study

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0 Published in 2022 at "International Journal of Reproductive Biomedicine"

DOI: 10.18502/ijrm.v20i5.11056

Abstract: Abstract Background Total fertilization failure (TFF) is associated with essential mechanistic and cellular events. Objective The present study is a comprehensive examination of detrimental effects with well-known assays for predicting TFF in conventional in vitro… read more here.

Keywords: quality; fertilization; fertilization failure; vitro fertilization ... See more keywords

Predicting the unexpected total fertilization failure in conventional in vitro fertilization cycles: What is the role of semen quality?

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2 Published in 2023 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2023.1133512

Abstract: Background: Male and female gametes factors might contribute to the total fertilization failure (TFF). In first in vitro fertilization (IVF) cycles, decision-making of insemination protocol was mainly based on semen quality for the contribution of… read more here.

Keywords: semen quality; fertilization; fertilization failure; semen parameters ... See more keywords