Determination of total and free voriconazole in human plasma: Application to pharmacokinetic study and therapeutic monitoring.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2019.112952
Abstract: Abstract • Voriconazole (VCZ) is highly efficient in the treatment of invasive fungal infections. However, the therapy requires the monitoring of VCZ plasma concentration, due to a narrow therapeutic index and large inter-individual variability of… read more here.
Keywords: determination total; plasma; total free; study ... See more keywords
Determination of free tyrosine in equestrian supplements by LC–MS/MS and comparison of its quantity with total free amino acids content in view of doping control
Sign Up to like & getrecommendations! Published in 2019 at "Microchemical Journal"
DOI: 10.1016/j.microc.2018.12.033
Abstract: Abstract The reports on the probable beneficial impact of tyrosine (TYR) supplementation on performance enhancement have contributed to the growth of interest in TYR in equestrian sports field and related industries, such as the manufacture… read more here.
Keywords: amino acids; tyrosine; determination; total free ... See more keywords
Correlative studies on vitamin D and total, free bioavailable testosterone levels in young, healthy men
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-99571-8
Abstract: The relationship between vitamin D levels and testicular hormonal function in men has not been clearly established. Therefore, we aimed to investigate the relationship between deficiency/insufficiency levels of 25(OH)D and luteinizing hormone (LH), follicle-stimulating hormone… read more here.
Keywords: free bioavailable; healthy men; total free; young healthy ... See more keywords
Simple Liquid Chromatography-Tandem Mass Spectrometry Method for Quantitation of Total and Free Aprepitant and its Active N-Dealkylated Metabolites in Human Plasma.
Sign Up to like & getrecommendations! Published in 2020 at "Therapeutic Drug Monitoring"
DOI: 10.1097/ftd.0000000000000815
Abstract: BACKGROUND Aprepitant, an antiemetic selective neurokinin-1 receptor antagonist, is primarily metabolized to the active N-dealkylated (ND-AP) form and then converted to its carbonyl (ND-CAP) form in humans. This study developed simple liquid chromatography-tandem mass spectrometry… read more here.
Keywords: dealkylated metabolites; active dealkylated; aprepitant; total free ... See more keywords
SAT-169 Healthy Ageing Men experience Decline of Sexual Function and Fertility Dependent on Increases of HbA1c within the Normal Range: the Longitudinal FAMe 2.0 study
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvaf149.2018
Abstract: Abstract Disclosure: M. Zitzmann: None. C. Krallmann: None. J. Cremers: None. S. Kliesch: None. S. Bier: None. The relevance of fertility and sexual wellbeing in aging men is rising. Notwithstanding, little is known especially about… read more here.
Keywords: increases hba1c; free testosterone; total free; within normal ... See more keywords
Determination of Total and Free Plasma Concentration of Liposomal Mitoxantrone and Clinical Application in Adult Patients with Relapsed or Refractory Peripheral T-Cell Lymphoma
Sign Up to like & getrecommendations! Published in 2025 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s542030
Abstract: Purpose Currently reported methods for determining plasma concentration of mitoxantrone primarily measure total drug concentration. However, methodologies for quantifying liposomal mitoxantrone, particularly the free drug fraction, are lacking. Since the free drug represents the pharmacologically… read more here.
Keywords: total free; cell lymphoma; mitoxantrone; liposomal mitoxantrone ... See more keywords
Assessment of Sex, Age, and Metabolism Relationships to Serum Thyroid Concentrations in Retired Alaskan Husky Sled Dogs
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2022.859066
Abstract: Sled dogs are purpose-bred dogs selected for endurance work. Prior studies in racing dogs showed that serum thyroid parameters (total T4, free T4, and T3) are lower than the reference range in approximately 25% of… read more here.
Keywords: total free; sled dogs; age; serum thyroid ... See more keywords
Lymphocyte Phenotypes and Protein-Bound Uremic Toxins as Determinants of Clinical Outcomes in Hemodialysis Patients
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms262110376
Abstract: The impact of protein bound uremic toxins (PBUTs) and lymphocyte alterations in morbidity and mortality in patients on hemodialysis (HD) is of great concern. The aim of this study was the assessment of association between… read more here.
Keywords: total free; uremic toxins; bound uremic; mortality ... See more keywords