Exposure-Response Analyses of the Effects of Venetoclax, a Selective BCL-2 Inhibitor, on B-Lymphocyte and Total Lymphocyte Counts in Women with Systemic Lupus Erythematosus
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DOI: 10.1007/s40262-019-00818-5
Abstract: Background Venetoclax is a selective inhibitor of B-cell lymphoma-2, which plays a role in the development of various autoimmune diseases including systemic lupus erythematosus. The aim of these analyses was to quantify the exposure-response relationship… read more here.
Keywords: lymphocyte counts; total lymphocyte; lupus erythematosus; systemic lupus ... See more keywords
Effect of Ponesimod Exposure on Total Lymphocyte Dynamics in Patients with Multiple Sclerosis
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DOI: 10.1007/s40262-021-01019-9
Abstract: The aim of this study was to characterize the relationship between ponesimod plasma concentrations and the temporal evolution of lymphocyte counts in multiple sclerosis (MS) patients. Population pharmacokinetic (PK) and PK/pharmacodynamic (PD) models were developed… read more here.
Keywords: lymphocyte counts; ponesimod; total lymphocyte; clinically relevant ... See more keywords