The safety and efficacy of a novel hypo-fractionated total marrow and lymphoid irradiation before allogeneic stem cell transplantation for lymphoma and acute leukemia
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Translational Radiation Oncology"
DOI: 10.1016/j.ctro.2020.11.004
Abstract: Highlights • TBI is an important part of conditioning regimens in patients undergoing HSCT.• Myeloablative regimens delivering 12 Gy/6F were most commonly employed.• No uniform standard on the optimal dosage of TMI and segmentation.• Our… read more here.
Keywords: total marrow; safety efficacy; hypo fractionated; efficacy novel ... See more keywords
Total marrow irradiation for hematopoietic malignancies using volumetric modulated arc therapy: A review of treatment planning studies☆☆☆
Sign Up to like & getrecommendations! Published in 2019 at "Physics and Imaging in Radiation Oncology"
DOI: 10.1016/j.phro.2019.08.001
Abstract: Total Marrow Irradiation (TMI) has been introduced in the management of hematopoietic malignancies with the aim of reducing toxicities induced by total body irradiation. TMI is one of the most challenging planning and delivery techniques… read more here.
Keywords: irradiation; total marrow; treatment planning; marrow irradiation ... See more keywords
Phase I trial of myeloablative conditioning with 3‐day total marrow and lymphoid irradiation for leukemia
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DOI: 10.1111/cas.15611
Abstract: This prospective phase I trial aimed to determine the recommended dose of 3‐day total marrow and lymphoid irradiation (TMLI) for a myeloablative conditioning regimen by increasing the dose per fraction. The primary end‐point of this… read more here.
Keywords: day total; day; phase trial; total marrow ... See more keywords
Organ sparing total marrow irradiation compared to total body irradiation prior to allogeneic stem cell transplantation
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DOI: 10.1111/ejh.13675
Abstract: Total body irradiation (TBI) is commonly used prior to hematopoietic stem cell transplantation (HSCT) in myeloablative conditioning regimens. However, TBI may be replaced by total marrow irradiation (TMI) at centres with access to Helical TomoTherapy,… read more here.
Keywords: irradiation; total body; total marrow; cell transplantation ... See more keywords
Total marrow irradiation in hematopoietic stem cell transplantation for hematologic malignancies
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2023.1155954
Abstract: Total body irradiation (TBI) has been an essential component of the conditioning regimen in hematopoietic cell transplantation for many years. However, higher doses of TBI reduce disease relapse at the expense of more significant toxicities.… read more here.
Keywords: cell transplantation; marrow irradiation; total marrow; irradiation ... See more keywords
Feasibility of a Novel Sparse Orthogonal Collimator–Based Preclinical Total Marrow Irradiation for Enhanced Dosimetric Conformality
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DOI: 10.3389/fonc.2022.941814
Abstract: Total marrow irradiation (TMI) has significantly improved radiation conditioning for hematopoietic cell transplantation in hematologic diseases by reducing conditioning-induced toxicities and improving survival outcomes in relapsed/refractory patients. Recently, preclinical three-dimensional image–guided TMI has been developed… read more here.
Keywords: orthogonal collimator; sparse orthogonal; marrow irradiation; novel sparse ... See more keywords
Internal Guidelines for Reducing Lymph Node Contour Variability in Total Marrow and Lymph Node Irradiation
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DOI: 10.3390/cancers15051536
Abstract: Simple Summary The lymph node clinical target volume (CTV_LN) contour in total marrow and lymph node irradiation (TMLI) is extremely complex and time-consuming, involving the delineation of numerous lymph node chains. Furthermore, as few patients… read more here.
Keywords: marrow lymph; variability; tmli; total marrow ... See more keywords
Total marrow and lymphoid irradiation with helical tomotherapy: a practical implementation report
Sign Up to like & getrecommendations! Published in 2020 at "Radiation Oncology Journal"
DOI: 10.3857/roj.2020.00528
Abstract: Purpose To standardize the technique; evaluate resources requirements and analyze our early experience of total marrow and lymphoid irradiation (TMLI) as part of the conditioning regimen before allogenic bone marrow transplantation using helical tomotherapy. Materials… read more here.
Keywords: total marrow; lymphoid irradiation; marrow lymphoid; helical tomotherapy ... See more keywords