A practical framework for the targeted use of total neoadjuvant therapy for rectal cancer
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DOI: 10.1002/cncr.34149
Abstract: Total neoadjuvant therapy (TNT) for rectal cancer is the preoperative delivery of radiation or chemoradiotherapy as well as systemic chemotherapy for the purpose of improving treatment completion rates and decreasing toxicity, maximizing the primary tumor… read more here.
Keywords: neoadjuvant therapy; cancer practical; total neoadjuvant; rectal cancer ... See more keywords
Total neoadjuvant therapy in rectal cancer: The FOREST protocol, a patient‐centered approach that clusters two cohorts with different outcomes
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DOI: 10.1002/ijc.70126
Abstract: Rectal cancer treatment has evolved toward individualized strategies that emphasize organ preservation and tailored therapeutic approaches. The FOREST protocol combines total neoadjuvant therapy (TNT), early response evaluation, and prehabilitation within a comprehensive framework designed to… read more here.
Keywords: cancer; protocol; neoadjuvant therapy; rectal cancer ... See more keywords
Total neoadjuvant therapy with six versus four cycles of CAPOX in locally advanced rectal cancer: A real-world study.
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DOI: 10.1002/ijc.70151
Abstract: The optimal number of systemic chemotherapies for total neoadjuvant therapy (TNT) in locally advanced rectal cancer (LARC) is controversial. This retrospective study, conducted at Fujian Medical University Union Hospital from January 2018 to April 2024,… read more here.
Keywords: cycles capox; cancer; capox group; neoadjuvant therapy ... See more keywords
MRI‐detected extramural vascular invasion (mrEMVI) as the best predictive factor to identify candidates to total neoadjuvant therapy in locally advanced rectal cancer
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DOI: 10.1002/jso.26818
Abstract: Chemotherapy in locally advanced rectal cancer (LARC) is shifting from an adjuvant setting to a total neoadjuvant therapy (TNT) strategy, that relies on distant metastases (DM) risk prediction. This study aims to assess the accuracy… read more here.
Keywords: locally advanced; neoadjuvant therapy; total neoadjuvant; rectal cancer ... See more keywords
Total neoadjuvant therapy is associated with improved overall survival and pathologic response in pancreatic adenocarcinoma
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DOI: 10.1002/jso.26906
Abstract: Few studies have evaluated outcomes of total neoadjuvant therapy (TNT) compared with single modality neoadjuvant therapy (SMNT) or surgery first (SF) for pancreatic ductal adenocarcinoma (PDAC). read more here.
Keywords: therapy associated; neoadjuvant therapy; therapy; total neoadjuvant ... See more keywords
Quality of life following total neoadjuvant therapy for rectal cancer
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DOI: 10.1007/s00432-025-06347-y
Abstract: This study aimed to assess the health-related quality of life (HRQoL) in patients with locally advanced rectal cancer (LARC) undergoing total neoadjuvant therapy (TNT), comparing outcomes with the German general population and colorectal cancer (CRC)… read more here.
Keywords: cancer; neoadjuvant therapy; quality life; rectal cancer ... See more keywords
Predicting Tumor Regrowth in Patients Undergoing Non-Operative Management after Total Neoadjuvant Therapy
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DOI: 10.1007/s12029-025-01342-5
Abstract: Total neoadjuvant treatment (TNT) has become the standard of care for locally advanced rectal cancer (LARC), leading to increased rates of complete clinical response and expanding the potential for organ preservation through non-operative management (NOM)… read more here.
Keywords: regrowth; patients undergoing; tumor regrowth; regrowth patients ... See more keywords
Total neoadjuvant therapy: Fact, fantasy, or fallacy?
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DOI: 10.1016/j.suronc.2022.101738
Abstract: Colorectal cancer is the second leading cause of cancer death in the United States for men and women, with an estimated 146,000 new cases per year - a staggering 53,000 patients die each year. Rectal… read more here.
Keywords: total neoadjuvant; neoadjuvant therapy; therapy fact; rectal cancer ... See more keywords
A prospective phase II clinical trial of total neoadjuvant therapy for locally advanced gastric cancer and gastroesophageal junction adenocarcinoma
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DOI: 10.1038/s41598-024-58177-6
Abstract: To investigate the safety and efficacy of the neoadjuvant chemoradiotherapy (NCRT) followed by neoadjuvant consolidation chemotherapy (NCCT) and surgery for locally advanced gastric cancer (GC) or gastroesophageal junction (GEJ) adenocarcinoma. Patients diagnosed as locally advanced… read more here.
Keywords: locally advanced; neoadjuvant therapy; total neoadjuvant; gastric cancer ... See more keywords
Total Neoadjuvant Therapy With Short-Course Radiation: US Experience of a Neoadjuvant Rectal Cancer Therapy.
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DOI: 10.1097/dcr.0000000000001997
Abstract: BACKGROUND Short-course radiation followed by chemotherapy as total neoadjuvant therapy has been investigated primarily in Europe and Australia with increasing global acceptance. There are limited data on this regimen's use in the United States, however,… read more here.
Keywords: neoadjuvant therapy; short course; therapy; total neoadjuvant ... See more keywords
Deep Learning-Based Model for Identifying Tumor in Endoscopic Images From Patients With Locally Advanced Rectal Cancer Treated With Total Neoadjuvant Therapy.
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DOI: 10.1097/dcr.0000000000002295
Abstract: BACKGROUND A barrier to the widespread adoption of watch-and-wait management for locally advanced rectal cancer is the inaccuracy and variability of identifying tumor response endoscopically in patients who have completed total neoadjuvant therapy (chemoradiotherapy and… read more here.
Keywords: identifying tumor; locally advanced; rectal cancer; neoadjuvant therapy ... See more keywords