A practical framework for the targeted use of total neoadjuvant therapy for rectal cancer
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DOI: 10.1002/cncr.34149
Abstract: Total neoadjuvant therapy (TNT) for rectal cancer is the preoperative delivery of radiation or chemoradiotherapy as well as systemic chemotherapy for the purpose of improving treatment completion rates and decreasing toxicity, maximizing the primary tumor… read more here.
Keywords: neoadjuvant therapy; cancer practical; total neoadjuvant; rectal cancer ... See more keywords
MRI‐detected extramural vascular invasion (mrEMVI) as the best predictive factor to identify candidates to total neoadjuvant therapy in locally advanced rectal cancer
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DOI: 10.1002/jso.26818
Abstract: Chemotherapy in locally advanced rectal cancer (LARC) is shifting from an adjuvant setting to a total neoadjuvant therapy (TNT) strategy, that relies on distant metastases (DM) risk prediction. This study aims to assess the accuracy… read more here.
Keywords: locally advanced; neoadjuvant therapy; total neoadjuvant; rectal cancer ... See more keywords
Total neoadjuvant therapy is associated with improved overall survival and pathologic response in pancreatic adenocarcinoma
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DOI: 10.1002/jso.26906
Abstract: Few studies have evaluated outcomes of total neoadjuvant therapy (TNT) compared with single modality neoadjuvant therapy (SMNT) or surgery first (SF) for pancreatic ductal adenocarcinoma (PDAC). read more here.
Keywords: therapy associated; neoadjuvant therapy; therapy; total neoadjuvant ... See more keywords
Total neoadjuvant therapy: Fact, fantasy, or fallacy?
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DOI: 10.1016/j.suronc.2022.101738
Abstract: Colorectal cancer is the second leading cause of cancer death in the United States for men and women, with an estimated 146,000 new cases per year - a staggering 53,000 patients die each year. Rectal… read more here.
Keywords: total neoadjuvant; neoadjuvant therapy; therapy fact; rectal cancer ... See more keywords
Total Neoadjuvant Therapy With Short-Course Radiation: US Experience of a Neoadjuvant Rectal Cancer Therapy.
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DOI: 10.1097/dcr.0000000000001997
Abstract: BACKGROUND Short-course radiation followed by chemotherapy as total neoadjuvant therapy has been investigated primarily in Europe and Australia with increasing global acceptance. There are limited data on this regimen's use in the United States, however,… read more here.
Keywords: neoadjuvant therapy; short course; therapy; total neoadjuvant ... See more keywords
Deep Learning-Based Model for Identifying Tumor in Endoscopic Images From Patients With Locally Advanced Rectal Cancer Treated With Total Neoadjuvant Therapy.
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DOI: 10.1097/dcr.0000000000002295
Abstract: BACKGROUND A barrier to the widespread adoption of watch-and-wait management for locally advanced rectal cancer is the inaccuracy and variability of identifying tumor response endoscopically in patients who have completed total neoadjuvant therapy (chemoradiotherapy and… read more here.
Keywords: identifying tumor; locally advanced; rectal cancer; neoadjuvant therapy ... See more keywords
Impact of Total Neoadjuvant Therapy on Postoperative Outcomes After Proctectomy for Rectal Cancer.
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DOI: 10.1097/dcr.0000000000002555
Abstract: BACKGROUND Total neoadjuvant therapy is an alternative to neoadjuvant chemoradiation alone for rectal cancer and has the benefits of more completion of planned therapy, increased down-staging, earlier treatment of micrometastases, and assessment of chemosensitivity; however,… read more here.
Keywords: neoadjuvant therapy; therapy; total neoadjuvant; neoadjuvant chemoradiation ... See more keywords
Total neoadjuvant therapy for rectal cancer: here and now
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DOI: 10.1111/ans.16153
Abstract: 2.2018, NCCN Clinical Practice Guidelines in Oncology. J. Natl. Compr. Canc. Netw. 2018; 16: 874–901. 9. Kalady MF, de Campos-Lobato LF, Stocchi L et al. Predictive factors of pathologic complete response after neoadjuvant chemoradiation for… read more here.
Keywords: rectal cancer; therapy rectal; neoadjuvant therapy; rectal ... See more keywords
Targeted lateral pelvic lymph node excision in the setting of total neoadjuvant therapy for rectal cancer
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DOI: 10.1111/ans.18149
Abstract: Targeted lateral pelvic node dissection in the era of total neoadjuvant therapy. read more here.
Keywords: neoadjuvant therapy; lateral pelvic; total neoadjuvant; targeted lateral ... See more keywords
Personalized total neoadjuvant therapy versus chemotherapy during the ‘wait period’ versus standard chemoradiotherapy for locally advanced rectal cancer
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DOI: 10.1111/ans.18229
Abstract: This study aimed to compare current treatment response rates with personalized Total Neoadjuvant Therapy (pTNT), against extended chemotherapy in the ‘wait period’ (xCRT) and standard chemoradiotherapy (sCRT) with adjuvant chemotherapy for rectal cancer. read more here.
Keywords: neoadjuvant therapy; standard chemoradiotherapy; total neoadjuvant; personalized total ... See more keywords
Institutional experience with total neoadjuvant therapy for low-lying rectal tumors.
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DOI: 10.1200/jco.2020.38.4_suppl.123
Abstract: 123Background: Surgery has traditionally been the primary treatment for rectal cancer with consideration of neoadjuvant and adjuvant therapies based on stage. Recent studies have shown that Total N... read more here.
Keywords: experience total; low lying; therapy low; institutional experience ... See more keywords