The Total Synthesis of Glycolipids from Streptococcus pneumoniae and a Re‐evaluation of Their Immunological Activity **
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DOI: 10.1002/cbic.202200361
Abstract: Invariant natural killer (iNK) T cells, Type I iNKTs, are responsible for the production of pro‐inflammatory cytokines which induce a systemic immune response. They are distinctive in possessing an semi‐invariant T‐cell receptor that recognizes glycolipid… read more here.
Keywords: evaluation; activity; total synthesis; receptor ... See more keywords
Hit to Leads with Cytotoxic Effect in Leukemic Cells: Total Synthesis Intermediates as a Molecule Treasure Chest
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DOI: 10.1002/cmdc.202000066
Abstract: A previously designed and developed 12‐step total synthesis that includes [1,1′‐biphenyl]‐2‐amine and carbazole intermediates and that ultimately produces the carbazole alkaloid carbazomycin G was exploited as a screening compound library with the goal of identifying… read more here.
Keywords: total synthesis; leads cytotoxic; cytotoxic effect; hit leads ... See more keywords
Construction and Biological Evaluation of Small Libraries Based on the Intermediates within the Total Synthesis of Uvaretin
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DOI: 10.1002/cmdc.202001010
Abstract: The synthesis of new small chemical screening libraries (CSL) constructed from the intermediates of our total synthesis route of the uvaretin class of natural products is demonstrated herein. Numerous chalcone based CSLs were assembled, with… read more here.
Keywords: evaluation small; construction biological; biological evaluation; total synthesis ... See more keywords
Total Synthesis of Pseudellone C
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DOI: 10.1002/ejoc.201700491
Abstract: The first chemical synthesis of a bisindole alkaloid, pseudellone C, was achieved in 44 % overall yield. The highlighting features of the synthesis include the fact that it is protecting-group free, economic and commercially available starting… read more here.
Keywords: pseudellone; chemistry; total synthesis; synthesis pseudellone ... See more keywords
Recent Applications of Rh‐ and Pd‐Catalyzed C(sp3)–H Functionalization in Natural Product Total Synthesis
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DOI: 10.1002/ejoc.201700641
Abstract: The advent of C(sp3)–H functionalization has heralded a paradigm shift in natural product synthesis. Indeed, several reports in which C–H functionalization serves as the key step in the synthesis have appeared over the years. The… read more here.
Keywords: sp3 functionalization; catalyzed sp3; total synthesis; natural product ... See more keywords
Asymmetric Total Synthesis of (–)-Gracilamine Using a Bioinspired Approach
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DOI: 10.1002/ejoc.201701474
Abstract: The asymmetric total synthesis of optically pure (–)-gracilamine (1) was achieved by employing a bioinspired approach. The strategy involved elaboration of 3a-arylhexahydroindole 7, a designed precursor, to 3a-formylarylhexahydroindole 5, which upon heating with l-leucine ethyl… read more here.
Keywords: asymmetric total; total synthesis; gracilamine; bioinspired approach ... See more keywords
Total Synthesis of Resveratrone and iso‐Resveratrone
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DOI: 10.1002/open.202200098
Abstract: Abstract The first total synthesis of resveratrone and iso‐resveratrone based on an epoxide olefination approach is described. The pivotal reaction proceeds by insertion of the lithiated epoxide into a boronic ester and subsequent syn‐elimination. Resveratrone… read more here.
Keywords: iso resveratrone; synthesis resveratrone; resveratrone; resveratrone iso ... See more keywords
Rapid Generation of Molecular Complexity by Chemical Synthesis: Highly Efficient Total Synthesis of Hexacyclic Alkaloid (-)-Chaetominine and Its Biosynthetic Implications.
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DOI: 10.1002/tcr.201800079
Abstract: The efficiency becomes a key issue in today's natural product total synthesis. While biomimetic synthesis is one of the most elegant strategies to achieve synthetic efficiency and thus to approach the ideal synthesis, most biogenetic… read more here.
Keywords: hexacyclic alkaloid; efficient total; total synthesis; alkaloid chaetominine ... See more keywords
TOTAL SYNTHESIS OF HAMACANTHIN B CLASS MARINE BISINDOLE ALKALOIDS
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DOI: 10.1007/5599
Abstract: A method for the synthesis of 1-(1H-indol-3-yl)ethane-1,2-diamines, key synthetic precursors of a number of marine alkaloids, has been developed based on the reduction of adducts of O-benzylhydroxylamine and N-protected 3-(2-nitrovinyl)indoles. For the first time, the… read more here.
Keywords: class marine; total synthesis; hamacanthin class; synthesis hamacanthin ... See more keywords
Total Synthesis of Cyclic Lipodepsipeptide Ophiotine
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DOI: 10.1007/s10600-020-03175-z
Abstract: The first total synthesis of the natural nematicidal cyclic lipodepsipeptide ophiotine via a convergent strategy that involved both solid-phase peptide synthesis and liquid phase chemistry is reported. The pre-made dipeptide building block was synthesized in… read more here.
Keywords: phase; cyclic lipodepsipeptide; lipodepsipeptide ophiotine; chemistry ... See more keywords
An Effective Approach to the Strychnos Alkaloids: Total Synthesis of Tubifolidine
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DOI: 10.1007/s10600-021-03394-y
Abstract: A facile total synthesis of tubifolidine has been developed, which is accomplished in an 11-step synthesis of the ABCDE pentacyclic of the strychnos alkaloids with an overall yield of 10%. The key steps are the… read more here.
Keywords: synthesis; effective approach; strychnos alkaloids; synthesis tubifolidine ... See more keywords