First Total Synthesis of Inaoside A
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DOI: 10.1002/ajoc.202400547
Abstract: The first total synthesis of inaoside A, an α‐D‐ribofuranoside isolated by our group from the edible mushroom Laetiporus cremeiporus, is described. The key reaction was an α‐selective Schmidt glycosylation. Most reported syntheses of ribofuranosides following… read more here.
Keywords: synthesis inaoside; total synthesis; first total; glycosylation ... See more keywords
The Total Synthesis of Glycolipids from Streptococcus pneumoniae and a Re‐evaluation of Their Immunological Activity **
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200361
Abstract: Invariant natural killer (iNK) T cells, Type I iNKTs, are responsible for the production of pro‐inflammatory cytokines which induce a systemic immune response. They are distinctive in possessing an semi‐invariant T‐cell receptor that recognizes glycolipid… read more here.
Keywords: evaluation; activity; total synthesis; receptor ... See more keywords
Stereoselective Total Synthesis of α‐Galacto‐Oligosaccharides Using Boron‐Mediated Aglycon Delivery and Evaluation of their Immune‐Enhancing Activities
Sign Up to like & getrecommendations! Published in 2025 at "Chembiochem"
DOI: 10.1002/cbic.202401059
Abstract: α‐Galacto‐oligosaccharides (α‐GOSs) are natural oligomeric saccharides found in plants that have garnered significant interest due to their indigestible nature and various biological activities. However, they often exist as inseparable mixtures, particularly long‐chain substances. This study… read more here.
Keywords: boron mediated; total synthesis; mediated aglycon; using boron ... See more keywords
Hit to Leads with Cytotoxic Effect in Leukemic Cells: Total Synthesis Intermediates as a Molecule Treasure Chest
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DOI: 10.1002/cmdc.202000066
Abstract: A previously designed and developed 12‐step total synthesis that includes [1,1′‐biphenyl]‐2‐amine and carbazole intermediates and that ultimately produces the carbazole alkaloid carbazomycin G was exploited as a screening compound library with the goal of identifying… read more here.
Keywords: total synthesis; leads cytotoxic; cytotoxic effect; hit leads ... See more keywords
Construction and Biological Evaluation of Small Libraries Based on the Intermediates within the Total Synthesis of Uvaretin
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DOI: 10.1002/cmdc.202001010
Abstract: The synthesis of new small chemical screening libraries (CSL) constructed from the intermediates of our total synthesis route of the uvaretin class of natural products is demonstrated herein. Numerous chalcone based CSLs were assembled, with… read more here.
Keywords: evaluation small; construction biological; biological evaluation; total synthesis ... See more keywords
Total Synthesis of an Epothilone Analogue based on the Amide‒Triazole Bioisosterism.
Sign Up to like & getrecommendations! Published in 2024 at "ChemPlusChem"
DOI: 10.1002/cplu.202400413
Abstract: Epothilones are 16-membered macrolides that can act as microtubule-targeting agents to tackle cancer. Many synthetic analogues have been investigated for their activity, yet often based on macrolide structures. A notable exception is Ixabepilone, an azalide… read more here.
Keywords: total synthesis; amide triazole; epothilone; triazole bioisosterism ... See more keywords
Total Synthesis of Pseudellone C
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DOI: 10.1002/ejoc.201700491
Abstract: The first chemical synthesis of a bisindole alkaloid, pseudellone C, was achieved in 44 % overall yield. The highlighting features of the synthesis include the fact that it is protecting-group free, economic and commercially available starting… read more here.
Keywords: pseudellone; chemistry; total synthesis; synthesis pseudellone ... See more keywords
Recent Applications of Rh‐ and Pd‐Catalyzed C(sp3)–H Functionalization in Natural Product Total Synthesis
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DOI: 10.1002/ejoc.201700641
Abstract: The advent of C(sp3)–H functionalization has heralded a paradigm shift in natural product synthesis. Indeed, several reports in which C–H functionalization serves as the key step in the synthesis have appeared over the years. The… read more here.
Keywords: sp3 functionalization; catalyzed sp3; total synthesis; natural product ... See more keywords
Asymmetric Total Synthesis of (–)-Gracilamine Using a Bioinspired Approach
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DOI: 10.1002/ejoc.201701474
Abstract: The asymmetric total synthesis of optically pure (–)-gracilamine (1) was achieved by employing a bioinspired approach. The strategy involved elaboration of 3a-arylhexahydroindole 7, a designed precursor, to 3a-formylarylhexahydroindole 5, which upon heating with l-leucine ethyl… read more here.
Keywords: asymmetric total; total synthesis; gracilamine; bioinspired approach ... See more keywords
Total Synthesis of the Repeating Unit of the O‐antigen from Proteus mirabilis OC (CCUG 10702) Serogroup O75: Step‐wise and One‐pot Approaches
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202400718
Abstract: Proteus mirabilis is a pathogenic gram‐negative bacterium that causes several kinds of infections in human beings. Herein, we present the first total synthesis of the O‐antigen tetrasaccharide repeating unit of P. mirabilis OC (CCUG 10702)… read more here.
Keywords: repeating unit; total synthesis; 10702 serogroup; proteus mirabilis ... See more keywords
Recent Advances in Sustainable Total Synthesis and Chiral Pool Strategies with Emphasis on (–)‐Sclareol in Natural Products Synthesis
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DOI: 10.1002/ejoc.202400983
Abstract: Starting materials for sustainable total synthesis often come from the chiral pool: carbohydrates, cyclitols, amino acids, and terpenes. In the terpene family, (–)‐sclareol has served as a sustainable, readily available, and versatile chiral building block… read more here.
Keywords: total synthesis; natural products; synthesis; chiral pool ... See more keywords