Articles with "total synuclein" as a keyword



GBA RNAi but not catalytic inhibition of glucocerebrosidase with Conduritol-β-epoxide increases levels of total α-synuclein in SH-SY5Y cells

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Published in 2019 at "Neuroscience Letters"

DOI: 10.1016/j.neulet.2019.05.027

Abstract: Mutations in the glucocerebrosidase gene are a common genetic risk factor for developing Parkinson's disease. The reasons why glucocerebrosidase mutations cause an increased life-time risk of developing Parkinson's disease are not fully understood. Here, we… read more here.

Keywords: glucocerebrosidase; total synuclein; conduritol epoxide; catalytic inhibition ... See more keywords
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Mechanisms underlying extensive Ser129-phosphorylation in α-synuclein aggregates

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Published in 2017 at "Acta Neuropathologica Communications"

DOI: 10.1186/s40478-017-0452-6

Abstract: Parkinson’s disease (PD) is characterized neuropathologically by intracellular aggregates of fibrillar α-synuclein, termed Lewy bodies (LBs). Approximately 90% of α-synuclein deposited as LBs is phosphorylated at Ser129 in brains with PD. In contrast, only 4%… read more here.

Keywords: total synuclein; phosphorylation; ser129 phosphorylation; synuclein ... See more keywords