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Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2019.05.027
Abstract: Mutations in the glucocerebrosidase gene are a common genetic risk factor for developing Parkinson's disease. The reasons why glucocerebrosidase mutations cause an increased life-time risk of developing Parkinson's disease are not fully understood. Here, we…
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Keywords:
glucocerebrosidase;
total synuclein;
conduritol epoxide;
catalytic inhibition ... See more keywords
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Published in 2017 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-017-0452-6
Abstract: Parkinson’s disease (PD) is characterized neuropathologically by intracellular aggregates of fibrillar α-synuclein, termed Lewy bodies (LBs). Approximately 90% of α-synuclein deposited as LBs is phosphorylated at Ser129 in brains with PD. In contrast, only 4%…
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Keywords:
total synuclein;
phosphorylation;
ser129 phosphorylation;
synuclein ... See more keywords