Depletion of Sorcs3 Activates Totipotency in Mouse Embryonic Stem Cells by Modulating Key Signaling Pathways.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202509151
Abstract: Totipotency represents the greatest potential to yield an entire individual alongside its associated extraembryonic tissues, albeit transiently. Nevertheless, achieving sustainable totipotent stem cells remains an intriguing yet challenging endeavor. Here, it is reported that Sorcs3… read more here.
Keywords: totipotency; depletion; stem cells; sko escs ... See more keywords
A CRISPR/Cas9 screen in embryonic stem cells reveals that Mdm2 regulates totipotency exit
Sign Up to like & getrecommendations! Published in 2024 at "Communications Biology"
DOI: 10.1038/s42003-024-06507-9
Abstract: During early embryonic development, the transition from totipotency to pluripotency is a fundamental and critical process for proper development. However, the regulatory mechanisms governing this transition remain elusive. Here, we conducted a comprehensive genome-wide CRISPR/Cas9… read more here.
Keywords: totipotency; cas9 screen; crispr cas9; stem cells ... See more keywords
Transition from totipotency to pluripotency in mice: insights into molecular mechanisms.
Sign Up to like & getrecommendations! Published in 2024 at "Biochemical Society transactions"
DOI: 10.1042/bst20230442
Abstract: Totipotency is the ability of a single cell to develop into a full organism and, in mammals, is strictly associated with the early stages of development following fertilization. This unlimited developmental potential becomes quickly restricted… read more here.
Keywords: totipotency; development; molecular mechanisms; transition totipotency ... See more keywords
RBBP4 is an epigenetic barrier for the induced transition of pluripotent stem cells into totipotent 2C-like cells.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad219
Abstract: Cellular totipotency is critical for whole-organism generation, yet how totipotency is established remains poorly illustrated. Abundant transposable elements (TEs) are activated in totipotent cells, which is critical for embryonic totipotency. Here, we show that the… read more here.
Keywords: totipotency; rbbp4; totipotent like; like cells ... See more keywords
Acquisition of 2C-like totipotency through defined maternal-effect factors.
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DOI: 10.1093/stmcls/sxae029
Abstract: Fully grown oocytes have the natural ability to transform two terminally differentiated gametes into a totipotent zygote representing acquisition of totipotency. This process wholly depends on maternal-effect factors (MFs). MFs stored in the eggs are… read more here.
Keywords: totipotency; maternal effect; stem cells; acquisition ... See more keywords