Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells.
Sign Up to like & getrecommendations! Published in 2022 at "Cell stem cell"
DOI: 10.1016/j.stem.2022.01.010
Abstract: Totipotent cells have more robust developmental potency than any other cell types, giving rise to both embryonic and extraembryonic tissues. Stable totipotent cell cultures and deciphering the principles of totipotency regulation would be invaluable to… read more here.
Keywords: totipotent like; like stem; stem cells; cell ... See more keywords
Relaxed 3D genome conformation facilitates the pluripotent to totipotent-like state transition in embryonic stem cells
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab1069
Abstract: Abstract The 3D genome organization is crucial for gene regulation. Although recent studies have revealed a uniquely relaxed genome conformation in totipotent early blastomeres of both fertilized and cloned embryos, how weakened higher-order chromatin structure… read more here.
Keywords: totipotent like; pluripotent totipotent; like state; genome conformation ... See more keywords
RBBP4 is an epigenetic barrier for the induced transition of pluripotent stem cells into totipotent 2C-like cells.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad219
Abstract: Cellular totipotency is critical for whole-organism generation, yet how totipotency is established remains poorly illustrated. Abundant transposable elements (TEs) are activated in totipotent cells, which is critical for embryonic totipotency. Here, we show that the… read more here.
Keywords: totipotency; rbbp4; totipotent like; like cells ... See more keywords