Genomic Strategies Toward Identification of Novel Therapeutic Targets.
Sign Up to like & getrecommendations! Published in 2020 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2020_360
Abstract: Coronary artery disease, myocardial infarction, and secondary damages of the myocardium in the form of ischemic heart disease remain major causes of death in Western countries. Beyond traditional risk factors such as smoking, hypertension, dyslipidemia,… read more here.
Keywords: genomic strategies; therapeutic targets; toward identification; identification novel ... See more keywords
Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL).
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01457
Abstract: Lysine acetylation is an epigenetic mark that is principally recognized by bromodomains, and recently structurally diverse YEATS domains also emerged as readers of lysine acetyl/acylations. Here we present a crystallography-based strategy and the discovery of… read more here.
Keywords: structure based; toward identification; identification; based approach ... See more keywords