Ligand-Installed Nanocarriers toward Precision Therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced materials"
DOI: 10.1002/adma.201902604
Abstract: Development of drug-delivery systems that selectively target neoplastic cells has been a major goal of nanomedicine. One major strategy for achieving this milestone is to install ligands on the surface of nanocarriers to enhance delivery… read more here.
Keywords: toward precision; installed nanocarriers; nanocarriers toward; ligand installed ... See more keywords
Detergents: Friends not foes for high‐performance membrane proteomics toward precision medicine
Sign Up to like & getrecommendations! Published in 2017 at "PROTEOMICS"
DOI: 10.1002/pmic.201600209
Abstract: Precision medicine, particularly therapeutics, emphasizes the atomic‐precise, dynamic, and systems visualization of human membrane proteins and their endogenous modifiers. For years, bottom‐up proteomics has grappled with removing and avoiding detergents, yet faltered at the therapeutic‐pivotal… read more here.
Keywords: medicine; precision medicine; membrane proteomics; toward precision ... See more keywords
Toward Precision Medicine In Neurodevelopmental Diseases
Sign Up to like & getrecommendations! Published in 2017 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2016.09.375
Abstract: Abstract One primary challenge in the interpretation of large-scale sequencing studies is the huge number of candidate variants that emerge. This occurs primarily because there are many functional variants in every sequenced genome and because… read more here.
Keywords: medicine; precision medicine; medicine neurodevelopmental; toward precision ... See more keywords
Toward precision manufacturing of immunogene T-cell therapies.
Sign Up to like & getrecommendations! Published in 2018 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2017.12.007
Abstract: Cancer can be effectively targeted using a patient's own T cells equipped with synthetic receptors, including chimeric antigen receptors (CARs) that redirect and reprogram these lymphocytes to mediate tumor rejection. Over the past two decades,… read more here.
Keywords: cell therapies; toward precision; precision manufacturing; immunogene cell ... See more keywords
Advances toward precision medicine for bipolar disorder: mechanisms & molecules
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Psychiatry"
DOI: 10.1038/s41380-020-0831-4
Abstract: Given its chronicity, contribution to disability and morbidity, and prevalence of more than 2%, the effective treatment, and prevention of bipolar disorder represents an area of significant unmet medical need. While more than half a… read more here.
Keywords: medicine; precision medicine; toward precision; bipolar disorder ... See more keywords
Toward a precision medicine approach for autoimmunity
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2204841119
Abstract: Autoimmune diseases are characterized by the immunemediated attack on seemingly healthy tissue. This attack is caused by a misdirected immune response to self-antigen. A key element of most autoimmune disorders is the recognition by T… read more here.
Keywords: toward precision; medicine; autoimmunity; precision medicine ... See more keywords
Subtypes of Delirium: A Step Toward Precision Medicine.
Sign Up to like & getrecommendations! Published in 2018 at "Critical Care Medicine"
DOI: 10.1097/ccm.0000000000003462
Abstract: 2058 www.ccmjournal.org December 2018 • Volume 46 • Number 12 postextubation complaints and perform laryngoscopy to visualize potential trauma. Perhaps the most important action we can take is prevention of intubation by alternative methods (i.e.,… read more here.
Keywords: medicine; subtypes delirium; step toward; toward precision ... See more keywords
Progresses Toward Precision Medicine in RET-altered Solid Tumors
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-20-1587
Abstract: RET (rearranged during transfection) gene encodes a receptor tyrosine kinase essential for many physiologic functions, but RET aberrations are involved in many pathologies. While RET loss-of-function mutations are associated with congenital disorders like Hirschsprung disease… read more here.
Keywords: toward precision; medicine; precision medicine; ret ... See more keywords
Abstract C068: Toward precision medicine for platinums
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-19-c068
Abstract: Over half of all cancer patients will receive a platinum drug during their treatment. Recent interest in our labs involve exploiting the high affinity of a discrete class of platinum-based anticancer agents, polynuclear platinum complexes… read more here.
Keywords: toward precision; medicine; cancer; abstract c068 ... See more keywords
Toward precision prescribing for methadone: Determinants of methadone deposition
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0231467
Abstract: Background Despite the World Health Organization listing methadone as an essential medication, effective dose selection is challenging, especially in racial and ethnic minority populations. Subtherapeutic doses can result in withdrawal symptoms while supratherapeutic doses can… read more here.
Keywords: cyp2b6; precision prescribing; methadone; toward precision ... See more keywords
Toward precision medicine in myotonic syndromes
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.15263
Abstract: The large number of physiological processes regulated by voltage-gated sodium channels (Na v) and their role in many diseases make these channels highly interesting as targets for new drugs. Current research in the pharmaceutical industry… read more here.
Keywords: medicine; sodium channel; toward precision; channel ... See more keywords