Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target.
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DOI: 10.1021/acs.jmedchem.1c01586
Abstract: With increasing drug resistance in tuberculosis (TB) patient populations, there is an urgent need for new drugs. Ideally, new agents should work through novel targets so that they are unencumbered by preexisting clinical resistance to… read more here.
Keywords: thioesterase; toward preclinical; activity; target ... See more keywords