Toward Single-Peak Dalbavancin Analogs through Biology and Chemistry.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical biology"
DOI: 10.1021/acschembio.9b00050
Abstract: Glycopeptide antibiotics are used to treat severe multidrug resistant infections caused by Gram-positive bacteria. Dalbavancin is a second generation glycopeptide approved for human use, which is obtained from A40926, a lipoglycopeptide produced by Nonomuraea sp.… read more here.
Keywords: dalbavancin analogs; single peak; chemistry; toward single ... See more keywords
Toward a Single-Dose Cure for Buruli Ulcer
Sign Up to like & getrecommendations! Published in 2020 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00727-20
Abstract: A single dose of Q203 (Telacebec), a phase 2 clinical candidate for tuberculosis, eradicates Mycobacterium ulcerans in a mouse model of Buruli ulcer infection without relapse up to 19 weeks posttreatment. Clinical use of Q203 may… read more here.
Keywords: q203; toward single; single dose; buruli ulcer ... See more keywords