Role of Lewis Acids toward the Synthesis of Tetrahydrofuran Motifs: An Update
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202500437
Abstract: Tetrahydrofurans (THFs) are an important structural unit in numerous biologically active compounds and pharmaceutical molecules. The development of an efficient strategies for THF‐based core synthesis has been one of the primary focus in synthetic chemistry,… read more here.
Keywords: chemistry; lewis acids; synthesis; role lewis ... See more keywords
Carbon-based leaving group capability of Meldrum’s acid in substitution reactions: a new strategy toward the synthesis of 4-phenyl-3, 4-dihydro-2H-benzo[g]chromene-2, 5, 10-triones
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-017-1129-6
Abstract: An efficient and straightforward method for the synthesis of new 5,5′-(2-benzylidenemalonyl)bis(2,2-dimethyl-1,3-dioxane-4,6-dione) derivatives by the reaction of Meldrum’s acid and aldehydes under mild reaction conditions is reported. Furthermore, the leaving group potency of Meldrum’s acid molecules… read more here.
Keywords: leaving group; meldrum acid; toward synthesis; synthesis ... See more keywords
Studies toward the Synthesis of Smenamide A, an Antiproliferative Metabolite from Smenospongia aurea: Total Synthesis of ent-Smenamide A and 16-epi-Smenamide A
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DOI: 10.1021/acsomega.7b00095
Abstract: A chiral pool protocol toward the synthesis of the smenamide family of natural products is described. Two stereoisomers of smenamide A, namely, ent-smenamide A and 16-epi-smenamide A were synthesized with a 2.6 and 2.5% overall… read more here.
Keywords: synthesis smenamide; smenamide; smenamide epi; toward synthesis ... See more keywords
Chemoenzymatic Approach toward the Synthesis of 3-O-(α/β)-Glucosylated 3-Hydroxy-β-lactams
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DOI: 10.1021/acsomega.8b01969
Abstract: Glycosylation significantly alters the biological and physicochemical properties of small molecules. β-Lactam alcohols comprise eligible substrates for such a transformation based on their distinct relevance in the chemical and medicinal community. In this framework, the… read more here.
Keywords: hydroxy lactams; toward synthesis; approach toward; synthesis ... See more keywords
Diversity-Oriented Approaches toward the Synthesis of Cyclophanes
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DOI: 10.1021/acsomega.9b00467
Abstract: Here, we describe synthetic approaches to a variety of cyclophanes involving transition-metal-catalyzed reactions such as the Suzuki–Miyaura cross-coupling, olefin metathesis, enyne metathesis, Glaser–Eglinton coupling, Yamamoto coupling, etc. On several occasions, alkylation, benzylation, Grignard reagents, and… read more here.
Keywords: chemistry; diversity oriented; synthesis cyclophanes; approaches toward ... See more keywords
Studies Toward the Synthesis of Caramboxin Analogues
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DOI: 10.21577/0103-5053.20180202
Abstract: Intrigued by the recent discovery of caramboxin by Brazilian researchers, we present the results from our studies toward the racemic synthesis of caramboxin analogs through the orthocarboxylation of 3,5-dimethoxy benzyl derivatives. Three different approaches were… read more here.
Keywords: studies toward; synthesis caramboxin; caramboxin; caramboxin analogues ... See more keywords
Isocyanide Reactions Toward the Synthesis of 3-(Oxazol-5-yl)Quinoline-2-Carboxamides and 5-(2-Tosylquinolin-3-yl)Oxazole
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DOI: 10.3389/fchem.2019.00433
Abstract: A palladium-catalyzed three-component reaction between 5-(2-chloroquinolin-3-yl) oxazoles, isocyanides, and water to yield 3-(oxazol-5-yl)quinoline-2-carboxamides is described. Interestingly, sulfonylation occurred when the same reaction was performed with toluenesulfonylmethyl isocyanide (TosMIC) as an isocyanide source. The reaction with… read more here.
Keywords: isocyanide reactions; oxazol quinoline; synthesis oxazol; quinoline carboxamides ... See more keywords
Studies toward synthesis of the core skeleton of spiroaspertrione A
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.1022533
Abstract: Bioassay-guided isolation of spiroaspertrione A from cultures of Aspergillus sp. TJ23 in 2017 demonstrated potent resensitization of oxacillin against methicillin-resistant Staphylococcus aureus by lowering the oxacillin minimal inhibitory concentration up to 32-fold. To construct this… read more here.
Keywords: toward synthesis; skeleton spiroaspertrione; synthesis core; studies toward ... See more keywords